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Completed
Fetal Hemoglobin Induction Treatment Metformin (External Link)
This is a dose escalation, pilot study for subjects with sickle cell anemia (SCA) disease to determine if metformin has a beneficial effect on the treatment and quality of life …
Baylor Role: Lead Sponsor
Completed
Prefrontal Cortical Engagement Through Non-Invasive Brain Stimulation in Schizophrenia (External Link)
Cognitive deficits are a strong predictor of functional outcome in schizophrenia, yet poorly remediated by current treatments. Disturbances in dorsolateral prefrontal cortex (DLPFC) function underlie core impairments such as in …
Baylor Role: Lead Sponsor
Recruiting
CD30 CAR T Cells, Relapsed CD30 Expressing Lymphoma (RELY-30) (External Link)
To prepare the CD30.CAR T cells, research staff will take some blood from the subject. This would be drawn as two separate blood collections. Alternatively, if the subject's blood counts …
Baylor Role: Lead Sponsor
Completed
Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study (External Link)
The investigators conducted a prospective, randomized, open label study at three clinical sites including Thomas Street Health Center and North West Clinic (Harris Health System), and the Michael E. DeBakey …
Baylor Role: Lead Sponsor
Completed
Growth and Microbiome Development in Very Low Birth Weight Infants Fed Primarily Mother's Own Milk vs. Donor Human Milk (External Link)
Background: Human milk feeding provides numerous benefits to preterm infants due to improvements in gastrointestinal maturation, host defense, infection rates, and improved long-term outcomes in neurodevelopment as well as cardiovascular …
Baylor Role: Lead Sponsor
Completed
Complementary Combination Therapy for Cocaine Dependence (External Link)
During a screening session participants will provide buccal swab for genetics testing, as preliminary data shows that effects of cocaine and of doxazosin are impacted significantly by the genotype at …
Baylor Role: Lead Sponsor
No Longer Available
Study of the Use of [18F]-DOPA in Hyperinsulinemic Hypoglycemia (External Link)
Hyperinsulinemic hypoglycemia is caused by low glucose due to excessive insulin secretion and remains difficult to treat because of the requirement for extensive amounts of glucose and the lack of …
Baylor Role: Lead Sponsor
Completed
Diabetes Strengths Study - Pilot of Provider-delivered Strengths-based Intervention (External Link)
The purpose of this study is to pilot test a newly developed strengths-based clinical intervention delivered by diabetes care providers in the context of routine ambulatory diabetes care, designed to …
Baylor Role: Lead Sponsor
Terminated
Fetal Cystoscopy for Lower Urinary Tract Obstruction (External Link)
Patients with severe LUTO will come for clinical evaluation as part of the standard clinical care at the Fetal Center at Texas Children's Hospital. Once the diagnosis of fetal severe …
Baylor Role: Lead Sponsor
Completed
Clinical Use of Baxter Animated Retching Faces (BARF) Scale in Children (External Link)
Pediatric research in the management of nausea has been limited by the absence of a reliable method to quantify the intensity of this subjective symptom. In adults, the visual analog …
Baylor Role: Lead Sponsor