Search Clinical Trials

34 Results

Completed
Pramipexole as a Treatment for Cocaine Dependence (External Link)
In this protocol we propose to assess the impact of treatment with higher doses of the potent D2/3 agonist pramipexole, using the extended release preparation that has been shown to …
Baylor Role: Lead Sponsor
Completed
Exercise as a Behavioral Treatment for Cocaine Dependence (External Link)
This proposal represents an important research effort with considerable public health significance in that it will provide detailed behavioral and physiological data for a non-pharmacological intervention to treat stimulant addiction. …
Baylor Role: Lead Sponsor
Withdrawn
Varenicline-Methamphetamine Interaction Study (2008) (External Link)
See Brief Summary
Baylor Role: Lead Sponsor
Completed
Doxazosin for Psychostimulant Dependence (External Link)
Psychostimulant dependence is a major public health problem and no medications have been shown to be very effective in treating this disorder. Thus, the investigators wish to study whether a …
Baylor Role: Collaborator
Withdrawn
Zonisamide Outpatient Study (External Link)
This is a randomized, double-blind, placebo-controlled study to examine the ability of 5-weeks treatment with zonisamide to reduce symptoms of PTSD and AUD. The study population will consist of 60 …
Baylor Role: Collaborator
Recruiting
A Study to Compare the Long-term Outcomes After Two Different Anaesthetics (External Link)
There is considerable evidence that most general anaesthetics modulate brain development in animal studies. The impact is greater with longer durations of exposure and in younger animals. There is great …
Baylor Role: Collaborator
Completed
Complementary Combination Therapy for Cocaine Dependence (External Link)
During a screening session participants will provide buccal swab for genetics testing, as preliminary data shows that effects of cocaine and of doxazosin are impacted significantly by the genotype at …
Baylor Role: Lead Sponsor
Completed
DOX as a Potential Treatment for Methamphetamine Dependence (External Link)
Purpose: To determine the effects of treatment with doxazosin, compared to treatment with placebo, on methamphetamine-induced craving and subjective effects in methamphetamine-dependent human volunteers. Secondary aims are to clarify the …
Baylor Role: Lead Sponsor
Completed
A Pilot Study of Cabergoline for the Treatment of Cocaine Dependence (External Link)
Secondary aims are to clarify the genetics of substance abuse, potentially leading to improved methods to diagnosis those at risk and to help develop better therapeutic interventions and to develop …
Baylor Role: Lead Sponsor
Withdrawn
RTI-336 as a Treatment for Methamphetamine Dependence (External Link)
Methamphetamine (METH) is a highly addictive stimulant and acute exposure causes dopamine (DA) release and stimulates midbrain reward centers. The proposed work represents an important research effort with considerable public …
Baylor Role: Lead Sponsor