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Recruiting
Cell Therapy for High Risk T-Cell Malignancies Using CD7-Specific CAR Expressed On Autologous T Cells (External Link)
To make the T cells, the investigators will take the patient's blood and stimulate it with growth factors to make the T cells grow. To get the CD7 antibody and …
Baylor Role: Lead Sponsor
Recruiting
Ex Vivo T-Cell Depletion of Mobilized Peripheral Blood Stem Cells Via CD34-Selection (External Link)
Participation in this project will last approximately one year with follow-up exams. Before treatment can begin, stem cells will be collected from the donor (a close relative) that has been …
Baylor Role: Lead Sponsor
Recruiting
Comparative Effectiveness of Two Acellular Matrices (Dermacell vs. Integra) for Management of Deep Diabetic Foot Ulcers (External Link)
Diabetes-related foot ulcers (DFUs) are a leading cause of hospitalization and amputation worldwide, and account for 33% of all direct costs of diabetes care in the US. Ulcers requiring acute …
Baylor Role: Lead Sponsor
Recruiting
CD30 CAR T Cells, Relapsed CD30 Expressing Lymphoma (RELY-30) (External Link)
To prepare the CD30.CAR T cells, research staff will take some blood from the subject. This would be drawn as two separate blood collections. Alternatively, if the subject's blood counts …
Baylor Role: Lead Sponsor
Recruiting
CRIC-Visceral Adiposity and Physical Fitness in Chronic Kidney Disease (External Link)
Obesity and chronic kidney disease (CKD) are major public health problems. Obesity independent of its relationship with diabetes and hypertension is associated with the development and progression of kidney disease. …
Baylor Role: Lead Sponsor
Recruiting
Effects of Transitional Circulation in ELBW Infants (External Link)
Screening Phase: The subject's parents/guardians/LAR will be approached if the infant's birth weight makes them eligible for this research study. Study Phase: During this study, we will use the monitoring …
Baylor Role: Lead Sponsor
Recruiting
Study of the Genetic and Epigenetic Causes of Recurrent Hydatidiform Moles (External Link)
Hydatidiform mole (HM) is the product of an aberrant human pregnancy in which there is abnormal embryonic development and abnormal proliferation of placental villi. The incidence of HM varies between …
Baylor Role: Lead Sponsor
Recruiting
Ferric Citrate in ESRD Pilot Project (External Link)
Iron deficiency anemia is very prevalent in end stage renal disease (ESRD) patients. Patients with ESRD require phosphate binders for hyperphosphatemia and erythropoiesis-stimulating agents (ESAs) and intravenous (IV) iron for …
Recruiting
BEnefits of Stroke Treatment Delivered Using a Mobile Stroke Unit (External Link)
There are many ways that use of a MSU might prove valuable in stroke patients, but we will focus on acute ischemic stroke (AIS) and treatment with IV tissue plasminogen …
Baylor Role: Collaborator
Recruiting
Radiation- and Alkylator-free Bone Marrow Transplantation Regimen for Patients With Dyskeratosis Congenita (External Link)
Dyskeratosis congenita (DC) is an inherited multisystem disorder, which classically presents with a clinical triad of skin pigment abnormalities, nail dystrophy, and oral leukoplakia. DC is part of a spectrum …
Baylor Role: Collaborator