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TRAIL-R2 and HER2 Bi-Specific Chimeric Antigen Receptor (CAR) T Cells for the Treatment of Metastatic Breast Cancer (External Link)
To make the T cells, the investigators will take the patient's blood and stimulate it with growth factors to make T cells grow. Investigators use a retrovirus to insert HER …
Baylor Role:
Lead Sponsor
Not Yet Recruiting
Heart Coherence Training on Vascular Ehlers-Danlos Syndrome Patients (External Link)
Vascular Ehlers Danlos Syndrome (VEDS) is caused by pathogenic variants of the COL3A1 gene, resulting abnormal Type III collagen protein. This impacts the body's connective tissue and makes people with …
Baylor Role:
Lead Sponsor
Recruiting
Marfan Syndrome Moderate Exercise Trial II (External Link)
Marfan syndrome (MFS) is a distinctive connective tissue disorder with clinical phenotypes that affect multiple organ systems including the heart, bones, ligaments, and eyes, and are associated with significant risk …
Baylor Role:
Lead Sponsor
Recruiting
Topical Dermaprazole for Radiation Dermatitis in Breast Cancer and Head and Neck Cancer Patients (TOPAZ) (External Link)
For this study, patients will be stratified into one of the following two arms: 1) head and neck or 2) breast cancer. All study participants will begin using Dermaprazole for …
Recruiting
Cardiopulmonary Outcomes in Osteogenesis Imperfecta: BBD7708 (External Link)
This study is cross-sectional. At the participant's one study visit, data will be obtained at a single point in time and reflect the patients' current condition. Evaluations will include family …
Baylor Role:
Lead Sponsor
Recruiting
Clear Aligners for the Treatment of Dental Malocclusion in OI (External Link)
Osteogenesis imperfecta (OI) is a heritable connective tissue disorder leading to frequent fractures and bone deformities. In about 90% of individuals with OI, the disease is caused by dominant mutations …
Baylor Role:
Lead Sponsor
Recruiting
Oxytocin for Hypermobile Ehlers-Danlos Syndrome (External Link)
This will be a single-site study to evaluate the effect of IV oxytocin on chronic pain in female adult patients with hypermobile EDS. Oxytocin secretion in the body is dynamic …
Baylor Role:
Lead Sponsor
Recruiting
Smart Boot Use to Measure Offloading Adherence (External Link)
The purpose of this study is to help people with diabetes who develop neuropathic diabetic foot ulcers (DFUs). These ulcers, or sores, if left untreated can increase the chance of …
Baylor Role:
Collaborator
Recruiting
Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders (External Link)
Histiocytic disorders are diseases caused by misfunctioning or buildup of particular immune cells called histiocytes. Many histiocytic disorders (LCH, juvenile xanthogranuloma (JXG), Erdheim-Chester disease (ECD), and Rosai-Dorfman Disease (RDD)) arises …
Baylor Role:
Collaborator
Completed
Marfan Syndrome Moderate Exercise Pilot (External Link)
Marfan syndrome (MFS) affects multiple organ systems including the heart, bones, ligaments, and eyes, and is associated with significant risk of aortic dissection. Given anecdotal reports of aortic dissection, limited …
Baylor Role:
Lead Sponsor