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Li-Fraumeni & TP53 (LiFT UP): Understanding and Progress (External Link)
This research study looks to enroll as many people with LFS or TP53 gene variants as possible in order to: - Better estimate cancer risks in individuals with TP53 variants …
Baylor Role: Collaborator
Recruiting
Penile Blood Flow Characteristics Following Caudal or Penile Block (External Link)
Pediatric urologic surgery is generally accompanied by use of a caudal or penile block for analgesia. A caudal block is performed by injecting local anesthetic in the low epidural space …
Baylor Role: Lead Sponsor
Recruiting
Technology Development for Noninvasive Prenatal Genetic Diagnosis Using Whole Fetal Cells From Maternal Peripheral Blood (External Link)
This is a revision to a project entitled "Prenatal Genetic Diagnosis by Genomic Sequencing: A Prospective Evaluation." This study proposes to test the utility and accuracy of a new form …
Baylor Role: Collaborator
Recruiting
Genetic Disorders of Obesity Program Database (External Link)
Children and adolescents who have suffered from severe weight gain prior to 5 years of age and who are seen in the Genetic Disorders of Obesity Program at Texas Children …
Baylor Role: Lead Sponsor
Active, Not Recruiting
Houston "Breathe Easy" Healthy Homes-Based Model for Multifamily Rental Communities (External Link)
This is a pragmatic randomized clinical trial that examines the effectiveness of a clinically informed phone-based environmental intervention for improving asthma control in individuals living in selected Houston Housing Authority …
Baylor Role: Lead Sponsor
Recruiting
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis (External Link)
Approximately 5,000 children die from septic shock each year in the United States (US); thousands more die worldwide. Most children admitted with sepsis receive initial resuscitation in an emergency department …
Baylor Role: Collaborator
Recruiting
Th-1 Dendritic Cell Immunotherapy Plus Standard Chemotherapy for Pancreatic Adenocarcinoma (External Link)
The primary objective of this phase 1, first in man trial is to determine the safety, toxicity, and feasibility of delivering autologous dendritic cells (DCs) loaded with pancreatic adenocarcinoma lysate …
Baylor Role: Lead Sponsor
Recruiting
HCRN Endoscopic Versus Shunt Treatment of Hydrocephalus in Infants (External Link)
The ESTHI Trial is a multi-center randomized controlled trial (RCT) comparing endoscopic third ventriculostomy with choroid plexus cauterization (ETV+CPC) and shunt in infants with hydrocephalus. The study will leverage the …
Baylor Role: Collaborator
Active, Not Recruiting
Adolescent Sexually Transmitted Infection Screening in the Emergency Department (External Link)
Adolescents are disproportionately affected by sexually transmitted infections (STIs). The STI epidemic among youth is a national public health priority as noted in the Healthy People 2020 objectives, which specifically …
Baylor Role: Collaborator
Recruiting
Chimeric Antigen Receptor T-cells for The Treatment of AML Expressing CLL-1 Antigen (External Link)
To make the CLL1-CD28 chimeric antigen receptor T cells, the investigators will collect the patient's blood and stimulate them with growth factors to make the cells grow. To get the …
Baylor Role: Lead Sponsor