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Recruiting
Clear Aligners for the Treatment of Dental Malocclusion in OI
Osteogenesis imperfecta (OI) is a heritable connective tissue disorder leading to frequent fractures and bone deformities. In about 90% of individuals with OI, the disease is caused by dominant mutations …
Baylor Role: Lead Sponsor
Recruiting
Imaging-Guided Low Intensity Focused Ultrasound (LIFU)
The current project will investigate a novel neurostimulation approach, low intensity focused ultrasound (LIFU), which combines non-invasiveness and a sharp spatial focus in deep brain regions. This open-label early feasibility …
Baylor Role: Lead Sponsor
Recruiting
HER2-specific Chimeric Antigen Receptor (CAR) T Cells for Children With Ependymoma
PBTC-059 is a multicenter, Phase I and Surgical study of the treatment HER2-specific CAR T cells for patients with refractory or recurrent ependymoma. Phase I The primary objectives of the …
Baylor Role: Collaborator
Active, Not Recruiting
Tolerability of Lopinavir Versus Dolutegravir for Children and Adolescents Living With HIV
Dolutegravir, an antiretroviral drug to treat HIV, has recently been rolled out on a large scale across much of Africa. With paediatric formulations becoming increasingly available, dolutegravir is set to …
Completed
Orthofeet: A Prospective Proof of Concept Trial to Evaluate an Innovative Pain Relief Footwear
A clinical study at the Baylor College of Medicine, to evaluate short and intermediate benefits and effectiveness of a novel pain relief footwear, called Orthofeet. This is a randomized crossed …
Not Yet Recruiting
Efficacy of ActiveMatrix on Spinal SSI Rate
Postoperative spinal surgical site infections (SSI) have a significant effect on patient morbidity and mortality.1 Spinal SSI as well as other complications including pseudoarthrosis occur at a higher rate in …
Baylor Role: Lead Sponsor
Recruiting
Nasotracheal Intubation With VL vs DL in Infants Trial
The primary objectives of the study are to compare the nasotracheal intubation (NTI) first attempt success rate using VL vs. DL in infants 0-365 days of age presenting for cardiothoracic …
Baylor Role: Collaborator
Recruiting
Uterine Transplant for Women With Absolute Uterine Factor Infertility (AUFI)
BACKGROUND: The feasibility of uterine transplant has been studied for more than a decade. The clinical concept and the technical aspects were first tested and proven in non-primates and then …
Withdrawn
CD19.CAR-multiVSTs for Patients With CD19+ B-ALL or NHL Undergoing Related Allogeneic HSCT (CARMA)
First, a donor gave us blood to make CD19 chimeric receptor multivirus specific T cells in the laboratory. These cells are grown and frozen for the patient. To make these …
Baylor Role: Lead Sponsor
Recruiting
Genetic Inclusion by Virtual Evaluation
Inadequate access to genetics evaluation and genomic testing in the Hispanic minorities living along the Texas-Mexico has marginalized the most vulnerable pediatric group. In this study, we will (1) implement …
Baylor Role: Lead Sponsor