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Recruiting
HCRN Endoscopic Versus Shunt Treatment of Hydrocephalus in Infants
The ESTHI Trial is a multi-center randomized controlled trial (RCT) comparing endoscopic third ventriculostomy with choroid plexus cauterization (ETV+CPC) and shunt in infants with hydrocephalus. The study will leverage the …
Baylor Role: Collaborator
Active, Not Recruiting
Adolescent Sexually Transmitted Infection Screening in the Emergency Department
Adolescents are disproportionately affected by sexually transmitted infections (STIs). The STI epidemic among youth is a national public health priority as noted in the Healthy People 2020 objectives, which specifically …
Baylor Role: Collaborator
Recruiting
Chimeric Antigen Receptor T-cells for The Treatment of AML Expressing CLL-1 Antigen
To make the CLL1-CD28 chimeric antigen receptor T cells, the investigators will collect the patient's blood and stimulate them with growth factors to make the cells grow. To get the …
Baylor Role: Lead Sponsor
Withdrawn
Peppermint Oil Pharmacokinetics/Dynamics
An initial single-dose PK study will be carried out. Forty-two children (n=21 per dose) will be randomized to receive approximately 10.9 mg·kg-1·d-1 of PMO or to receive approximately 18.2 mg·kg-1·d-1 …
Baylor Role: Lead Sponsor
Completed
Utility of OverStitch Sx After ESD
Resection of gastrointestinal neoplastic lesions at an early stage has been associated with improved clinical outcomes. While surgery has been traditionally performed for the resection of these precancerous or cancerous …
Baylor Role: Lead Sponsor
Recruiting
CD19.CAR Allogeneic NKT for Patients With Relapsed or Refractory B-Cell Malignancies (ANCHOR)
Earlier, a healthy donor provided blood to make ANCHOR cells in the laboratory. These cells were grown and frozen for later use. To make the ANCHOR cells, the investigators took …
Baylor Role: Lead Sponsor
Recruiting
Statins In Intracerbral Hemorrhage
SATURN is a multi-center, pragmatic, prospective, randomized, open-label, and blinded end-point assessment (PROBE) clinical trial. A total of 1,456 patients presenting within 7 days of a spontaneous lobar ICH while …
Baylor Role: Collaborator
Active, Not Recruiting
BCG Vaccine for Health Care Workers as Defense Against COVID 19
Study design: A placebo-controlled adaptive multi-center randomized controlled trial. Study population: High risk HCW with direct patient contacts, defined as physician assistants, respiratory therapists, nurses, physicians or other HCWs working …
Baylor Role: Collaborator
Completed
Study of the Treatment and Outcomes in Critically Ill Patients With COVID-19
The goals of this project are to determine the independent risk factors for hospital mortality and acute organ injury, and to identify treatment strategies associated with improved survival. Additionally, we …
Baylor Role: Collaborator
Recruiting
The Effect of Fluids on Aortic VTI During C-section
Pregnancy is associated with a myriad of physiologic changes, including expansion of blood volume, decrease in oncotic pressure, and increased cardiac output. Comorbidities including maternal hypertension, renal or cardiac disease …
Baylor Role: Lead Sponsor