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Completed
DOX as a Potential Treatment for Methamphetamine Dependence
Purpose: To determine the effects of treatment with doxazosin, compared to treatment with placebo, on methamphetamine-induced craving and subjective effects in methamphetamine-dependent human volunteers. Secondary aims are to clarify the …
Baylor Role: Lead Sponsor
Completed
Varenicline as a Treatment for Methamphetamine Dependence
This study is part of an effort to develop treatments for methamphetamine abuse. Varenicline is a drug that changes levels of certain brain chemicals that may also be useful in …
Baylor Role: Lead Sponsor
Completed
Carvedilol for Psychostimulant Dependence
This study examines whether carvedilol prolongs abstinence in recently abstinent cocaine dependent participants.
Baylor Role: Collaborator
Completed
Modafinil - Escitalopram Study for Cocaine Dependence
In this application, we propose an augmentation strategy intended to improve the efficacy of modafinil as a potential treatment for cocaine dependence. Recent data indicates that during chronic treatment modafinil …
Baylor Role: Lead Sponsor
Completed
Multisite Controlled Trial of Cocaine Vaccine
This 18-week, placebo-controlled randomized clinical trial among 300 cocaine dependent patients is designed to test the efficacy of a newly developed active vaccine against cocaine (TA-CD). TA-CD vaccine consists of …
Baylor Role: Lead Sponsor
Completed
NAC as a Potential Treatment for Methamphetamine Dependence
N-acetyl-l-cysteine (NAC) treatment is associated with reduced susceptibility to reinstatement of cocaine seeking behavior in rats (Baker et al 2002) and with reduced cue-induced craving in cocaine-dependent human volunteers (LaRowe …
Baylor Role: Lead Sponsor
Completed
Pharmacogenetics of Doxazosin for Cocaine Dependence
The NE system, especially the alpha 1-adrenergic receptor, may play an important role in cocaine addiction in humans. The results of this study will provide medical safety data on the …
Baylor Role: Lead Sponsor
Completed
The Effects of Doxazosin on the Cardiovascular and Subjective Effects of Cocaine
Primary Objective: The primary objective is to determine the safety of treatment with doxazosin in cocaine-dependent volunteers by examining hemodynamic and subjective effects of administration of ascending doses of cocaine …
Baylor Role: Lead Sponsor
Completed
The Efficacy of Doxazosin for Cocaine Users
The NE system, especially the alpha 1-adrenergic receptor, may play an important role in cocaine addiction in humans. The results of this study will provide medical safety data on the …
Baylor Role: Lead Sponsor
Completed
Nepicastat for Posttraumatic Stress Disorder (PTSD) in OIF/OEF Veterans
HYPOTHESES Primary Hypothesis: Compared to placebo treatment, nepicastat-treated OIF/OEF veterans with PTSD will have significantly reduced PTSD hyperarousal symptoms as defined by the Clinician Administered PTSD Scale [CAPS], subscale D …
Baylor Role: Collaborator