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Completed
Effects of Erythropoietin on Cerebral Vascular Dysfunction and Anemia in Traumatic Brain Injury (External Link)
Traumatic brain injury (TBI) causes a spectrum of cerebrovascular dysfunction, ranging from impaired pressure autoregulation to severe global ischemia (inadequate blood flow). Pressure autoregulation is the ability of an organ …
Completed
Namenda (Memantine) for Non-motor Symptoms in Parkinson's Disease (External Link)
Patients were enrolled over 11 months from the Parkinson Disease Center and Movement Disorder Clinic at Baylor College of Medicine. PD was diagnosed using standard criteria. Specific inclusion criteria were …
Baylor Role:
Lead Sponsor
Completed
Characterization of Angelman Syndrome (External Link)
AS is a developmental disorder that affects movement, speech, and social demeanor. The disorder is caused by a deficiency of a maternally transmitted gene and is inherited at birth. Children …
Baylor Role:
Collaborator
Completed
Phase 1 Intrathecal Topotecan for Neoplastic Meningitis (External Link)
This is a multi-center, non-randomized pharmacokinetically-guided optimal dosing study of intraventricular topotecan in children with neoplastic meningitis. Topotecan will be administered daily for five consecutive days utilizing the schema shown …
Baylor Role:
Lead Sponsor
Completed
An Open-label Study to Determine the Efficacy and Safety of Topiramate in the Treatment of Tourette Syndrome. (External Link)
In order to enroll in this study, you must have completed the Double-Blind phase of CAPSS-176 or discontinued the Double-Blind phase of CAPSS-176 after a minimum of 6 weeks because …
Baylor Role:
Lead Sponsor
Completed
A Randomized, Placebo-controlled, Tourette Syndrome Study. (External Link)
This study consists of three phases: Screening/Washout Phase, Double-Blind Phase and Taper Phase. SCREENING/WASHOUT PHASE: Your study doctor or his staff will review with you any medications that you are …
Baylor Role:
Lead Sponsor
Completed
Trial of Xyrem for Excessive Daytime Sleepiness and Sleep Disturbance in Parkinson's Disease (PD) (External Link)
Inclusion required an Epworth Sleepiness Scale (ESS) score greater than 10 and any subjective nocturnal sleep concern, usually insomnia. An acclimation and screening polysomnogram was performed to exclude subjects with …
Baylor Role:
Lead Sponsor
Completed
Prevention of Urinary Tract Infection (UTI) in Persons With Spinal Cord Injury (SCI) (External Link)
This clinical trial will be take place in a total of 7 medical centers that care for Spinal cord injury (SCI) and Spina Bifida patients. A total of 160 patients …
Baylor Role:
Lead Sponsor
Completed
Intervention for Stroke Survivors and Their Spousal Caregivers (External Link)
This 5-year randomized intervention study uses an advanced practice nurse, with the assistance of an interdisciplinary rehabilitation team, to provide education, support, skill training, counseling, and social and community linkages …
Baylor Role:
Collaborator
Completed
Study of Systemic and Spinal Chemotherapy Followed by Radiation for Infants With Brain Tumors (External Link)
All children in the study will receive Regimen 1 chemotherapy. Children whose tumor is limited to one area at the beginning of the study will go on to have radiation …
Baylor Role:
Lead Sponsor