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Completed
Prefrontal Cortical Engagement Through Non-Invasive Brain Stimulation in Schizophrenia (External Link)
Cognitive deficits are a strong predictor of functional outcome in schizophrenia, yet poorly remediated by current treatments. Disturbances in dorsolateral prefrontal cortex (DLPFC) function underlie core impairments such as in …
Baylor Role:
Lead Sponsor
Completed
Efficacy of Audio Recorded Guided Imagery vs Deep Breathing Exercises on Functional Gastrointestinal Pain Disorders (External Link)
Children managed in primary care with a functional gastrointestinal pain disorder will be recruited and studied for this trial. After participants are deemed eligible, they will complete multiple questionnaires and …
Baylor Role:
Lead Sponsor
Completed
Telehealth Depression Treatments for Older Adults (External Link)
The long-term objective of the proposed study is to improve access to depression treatments for low-income, racially diverse homebound seniors, a population experiencing significant disparities in mental health care due …
Baylor Role:
Collaborator
Completed
A Salivary miRNA Diagnostic Test for Autism (External Link)
The central aim of this project is to validate a panel of expressed microRNA (miRNA) in the saliva of children identified at risk for developing ASD by the MCHAT-R. Further, …
Baylor Role:
Collaborator
Completed
A Study of Transcorporal Versus Standard Artificial Urinary Sphincter Placement (External Link)
The AUS is the gold standard for treatment of severe SUI, particularly in patients following surgical resection of the prostate for prostate cancer. In fact, severe urinary incontinence can be …
Baylor Role:
Collaborator
Completed
Complementary Combination Therapy for Cocaine Dependence (External Link)
During a screening session participants will provide buccal swab for genetics testing, as preliminary data shows that effects of cocaine and of doxazosin are impacted significantly by the genotype at …
Baylor Role:
Lead Sponsor
Completed
Fast-Fail Trials in Mood and Anxiety Spectrum Disorders; Kappa Opioid Receptor Phase 2a (External Link)
FAST-MAS addresses an important problem and critical barrier to progress in Mood and Anxiety Spectrum Disorders and if the aims of the project are achieved, FAST-MAS could shift scientific knowledge, …
Baylor Role:
Collaborator
Completed
Aggression Prevention Training for Caregivers of Persons With Dementia (APT) (External Link)
Eighty percent of PWD have behavioral or psychological disturbances, including 40% that are aggressive behaviors. The prevalence of pain in PWD is about 60%, and it is a strong predictor …
Baylor Role:
Lead Sponsor
Completed
Double-Blind, Placebo-Controlled Trial of Ketamine Therapy in Treatment-Resistant Depression (TRD) (External Link)
The primary objective is to investigate whether all doses (0.1 mg/kg, 0.2 mg/kg, 0.5 mg/kg, and 1.0 mg/kg) of ketamine are superior to active placebo (midazolam 0.045 mg/kg) therapy in …
Baylor Role:
Collaborator
Completed
Pharmacogenetic Trial of Doxazosin for Treatment of Cocaine Abuse (External Link)
The noradrenergic system, especially the alpha 1-adrenergic receptor, may play an important role in cocaine addiction in humans. Doxazosin is a long-acting and selective alpha 1-adrenergic receptor blocker, which inhibits …
Baylor Role:
Collaborator