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38 Results
Withdrawn
Safe Return and Disposal of Unused Opioids
Participants identified by the PI and participating research staff/coordinators that will receive opioids following discharge will be approached. The participant information sheet will be provided to the parents/legal guardian and …
Baylor Role: Lead Sponsor
Completed
Review of Diagnostic Yield of MRI Brain Results in Children Under Age 3 Years
On December 14, 2016 the FDA issued a warning regarding elective anesthetics in children under three years of age. While a single, short exposure to general anesthesia may not have …
Baylor Role: Lead Sponsor
Active, Not Recruiting
A Study to Compare the Long-term Outcomes After Two Different Anaesthetics
There is considerable evidence that most general anaesthetics modulate brain development in animal studies. The impact is greater with longer durations of exposure and in younger animals. There is great …
Baylor Role: Collaborator
Completed
Complementary Combination Therapy for Cocaine Dependence
During a screening session participants will provide buccal swab for genetics testing, as preliminary data shows that effects of cocaine and of doxazosin are impacted significantly by the genotype at …
Baylor Role: Lead Sponsor
Completed
Pharmacogenetic Trial of Doxazosin for Treatment of Cocaine Abuse
The noradrenergic system, especially the alpha 1-adrenergic receptor, may play an important role in cocaine addiction in humans. Doxazosin is a long-acting and selective alpha 1-adrenergic receptor blocker, which inhibits …
Baylor Role: Collaborator
Completed
Carisbamate as a Potential Treatment for Alcohol Dependence
This within-subjects placebo-controlled experimental protocol will assess the effects of carisbamate (600mg qd) on the positive subjective effects of alcohol in non-treatment-seeking alcohol-dependent volunteers. Participants will receive study drug (carisbamate …
Baylor Role: Lead Sponsor
Terminated
A Pilot Study of Candesartan as a Treatment for Cocaine Dependence
The noradrenergic system may play an important role in cocaine addiction in humans. Angiotensin II (Ang II) is known to enhance noradrenergic activity, which contributes to effects on blood pressure …
Baylor Role: Lead Sponsor
Completed
Pramipexole as a Treatment for Cocaine Dependence
In this protocol we propose to assess the impact of treatment with higher doses of the potent D2/3 agonist pramipexole, using the extended release preparation that has been shown to …
Baylor Role: Lead Sponsor
Completed
Exercise as a Behavioral Treatment for Cocaine Dependence
This proposal represents an important research effort with considerable public health significance in that it will provide detailed behavioral and physiological data for a non-pharmacological intervention to treat stimulant addiction. …
Baylor Role: Lead Sponsor
Completed
A Pilot Study of Cabergoline for the Treatment of Cocaine Dependence
Secondary aims are to clarify the genetics of substance abuse, potentially leading to improved methods to diagnosis those at risk and to help develop better therapeutic interventions and to develop …
Baylor Role: Lead Sponsor