Search Clinical Trials
Completed
A Pilot Study of Cabergoline for the Treatment of Cocaine Dependence (External Link)
Secondary aims are to clarify the genetics of substance abuse, potentially leading to improved methods to diagnosis those at risk and to help develop better therapeutic interventions and to develop …
Baylor Role:
Lead Sponsor
Completed
Doxazosin for Psychostimulant Dependence (External Link)
Psychostimulant dependence is a major public health problem and no medications have been shown to be very effective in treating this disorder. Thus, the investigators wish to study whether a …
Baylor Role:
Collaborator
Completed
DOX as a Potential Treatment for Methamphetamine Dependence (External Link)
Purpose: To determine the effects of treatment with doxazosin, compared to treatment with placebo, on methamphetamine-induced craving and subjective effects in methamphetamine-dependent human volunteers. Secondary aims are to clarify the …
Baylor Role:
Lead Sponsor
Completed
Varenicline as a Treatment for Methamphetamine Dependence (External Link)
This study is part of an effort to develop treatments for methamphetamine abuse. Varenicline is a drug that changes levels of certain brain chemicals that may also be useful in …
Baylor Role:
Lead Sponsor
Completed
Carvedilol for Psychostimulant Dependence (External Link)
This study examines whether carvedilol prolongs abstinence in recently abstinent cocaine dependent participants.
Baylor Role:
Collaborator
Completed
Modafinil - Escitalopram Study for Cocaine Dependence (External Link)
In this application, we propose an augmentation strategy intended to improve the efficacy of modafinil as a potential treatment for cocaine dependence. Recent data indicates that during chronic treatment modafinil …
Baylor Role:
Lead Sponsor
Completed
Multisite Controlled Trial of Cocaine Vaccine (External Link)
This 18-week, placebo-controlled randomized clinical trial among 300 cocaine dependent patients is designed to test the efficacy of a newly developed active vaccine against cocaine (TA-CD). TA-CD vaccine consists of …
Baylor Role:
Lead Sponsor
Completed
NAC as a Potential Treatment for Methamphetamine Dependence (External Link)
N-acetyl-l-cysteine (NAC) treatment is associated with reduced susceptibility to reinstatement of cocaine seeking behavior in rats (Baker et al 2002) and with reduced cue-induced craving in cocaine-dependent human volunteers (LaRowe …
Baylor Role:
Lead Sponsor
Completed
Pharmacogenetics of Doxazosin for Cocaine Dependence (External Link)
The NE system, especially the alpha 1-adrenergic receptor, may play an important role in cocaine addiction in humans. The results of this study will provide medical safety data on the …
Baylor Role:
Lead Sponsor
Completed
The Effects of Doxazosin on the Cardiovascular and Subjective Effects of Cocaine (External Link)
Primary Objective: The primary objective is to determine the safety of treatment with doxazosin in cocaine-dependent volunteers by examining hemodynamic and subjective effects of administration of ascending doses of cocaine …
Baylor Role:
Lead Sponsor