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Search Clinical Trials
Completed
Choices4Health: Intervention to Prevent Substance-exposed Pregnancy (External Link)
A randomized group design (N = 240) will be used to test the efficacy of the C4H-C and C4H-T interventions relative to Brief Advice (BA) to reduce the risk of …
Baylor Role:
Collaborator
Completed
N-Acetylcysteine in Biliary Atresia After Kasai Portoenterostomy (External Link)
Biliary atresia (BA) is a disease characterized by fibro-obliteration of extrahepatic bile ducts leading to impaired bile flow (Sokol et al., 2007). BA is treated with the Kasai portoenterostomy (KP), …
Baylor Role:
Lead Sponsor
Completed
Efficacy of Na-GST-1/Alhydrogel Hookworm Vaccine Assessed by Controlled Challenge Infection (External Link)
Double blind, randomized, controlled, Phase 2 clinical trial in hookworm-unexposed adults living in the metropolitan area of Washington, DC. Subjects will receive three doses of the assigned vaccine formulation, or …
Baylor Role:
Lead Sponsor
Completed
Tranexamic Acid Per Inhalation for Treatment of Pulmonary Hemorrhage in Pediatric Patients (External Link)
Pulmonary hemorrhage can be severe and life-threatening. In children, etiologies of pulmonary hemorrhage include respiratory infection, foreign bodies, bronchiectasis, pulmonary vascular disorders, parenchymal lung disease, and post-surgical complications. Initial management …
Baylor Role:
Lead Sponsor
Completed
Na-GST-1/Alhydrogel With or Without CpG 10104 in Gabonese Adults (External Link)
Double blind, randomized, controlled, dose-escalation Phase 1 clinical trial in hookworm-exposed adults aged 18 to 50 years living in the area of Lambaréné, Gabon. Participants will receive three doses of …
Baylor Role:
Lead Sponsor
Completed
Entolimod, an Adjuvant for Vaccine Augmentation (External Link)
This is a single-blind (participants are blinded), pilot study with no therapeutic or diagnostic intent and limited drug exposure. The study will be conducted at Baylor College of Medicine in …
Baylor Role:
Lead Sponsor
Completed
Safety of Fresolimumab in the Treatment of Osteogenesis Imperfecta (External Link)
Osteogenesis Imperfecta (OI) is a rare disorder that causes bones to break easily. People with OI may have broken bones with little or no trauma, dentinogenesis imperfecta (DI), and, in …
Baylor Role:
Lead Sponsor
Completed
Effect of Monochromatic Light on Incidence of Emergence Delirium in Children (External Link)
Emergence delirium/emergence agitation (ED/EA) is a behavioral phenomenon of unclear etiology consisting of short lived behavioral changes that can be both traumatic to families and pose a safety risk to …
Baylor Role:
Lead Sponsor
Completed
Review of Diagnostic Yield of MRI Brain Results in Children Under Age 3 Years (External Link)
On December 14, 2016 the FDA issued a warning regarding elective anesthetics in children under three years of age. While a single, short exposure to general anesthesia may not have …
Baylor Role:
Lead Sponsor
Completed
Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD (External Link)
Argininosuccinate lyase deficiency (ASLD; also known as argininosuccinic aciduria) is the second most common urea cycle disorder (UCD) and accounts for 15-20% of all disorders of ureagenesis. Individuals with ASLD …
Baylor Role:
Lead Sponsor