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133 Results
Completed
Research Study for Major Depressive Disorder: Investigation of Glutamate Medications
This research proposal will investigate a glutamate-modulating agent, riluzole, in treatment-resistant patients who exhibit an acute, sustained response to a single dose of intravenous (IV) racemic ketamine. Fifty ketamine-responders will …
Baylor Role: Lead Sponsor
Completed
Effectiveness of Tropisetron Plus Risperidone for Improving Cognitive and Perceptual Disturbances in Schizophrenia
Schizophrenia is a chronic and disabling brain disorder. People with schizophrenia may experience hallucinations, delusions, disordered thinking, movement disorders, social withdrawal, and cognitive deficits. In considering the high rate of …
Baylor Role: Lead Sponsor
Completed
Substance P Antagonist in the Treatment of Posttraumatic Stress Disorder
Posttraumatic Stress Disorder (PTSD) is a common chronic anxiety disorder that is often debilitating and follows exposure to an overwhelming traumatic event. The burden of PTSD on individuals and society …
Baylor Role: Lead Sponsor
Withdrawn
Acamprosate for Treatment of Compulsive Behaviors and Craving in Parkinson's Disease
The purpose of this study is to determine how many patients with Parkinson's disease have compulsive behaviors, and what types of behaviors they have. This study will also determine if …
Baylor Role: Lead Sponsor
Completed
A Study of the Relationship Between Disulfiram and Cocaine Self-administration.
The problem of cocaine dependence remains a major medical, social, and legal concern. Several studies have suggested that disulfiram may be beneficial for the treatment of cocaine dependence. A common …
Baylor Role: Lead Sponsor
Completed
Pharmacogenetics of Disulfiram for Cocaine
Dopamine, a type of neurotransmitter, is the brain's "feel good" chemical. The amount of dopamine in the body may be an important factor in how cocaine addicts respond to treatment. …
Baylor Role: Lead Sponsor
Completed
An Open-label Study to Determine the Efficacy and Safety of Topiramate in the Treatment of Tourette Syndrome.
In order to enroll in this study, you must have completed the Double-Blind phase of CAPSS-176 or discontinued the Double-Blind phase of CAPSS-176 after a minimum of 6 weeks because …
Baylor Role: Lead Sponsor
Completed
A Randomized, Placebo-controlled, Tourette Syndrome Study.
This study consists of three phases: Screening/Washout Phase, Double-Blind Phase and Taper Phase. SCREENING/WASHOUT PHASE: Your study doctor or his staff will review with you any medications that you are …
Baylor Role: Lead Sponsor
Completed
Trial of Xyrem for Excessive Daytime Sleepiness and Sleep Disturbance in Parkinson's Disease (PD)
Inclusion required an Epworth Sleepiness Scale (ESS) score greater than 10 and any subjective nocturnal sleep concern, usually insomnia. An acclimation and screening polysomnogram was performed to exclude subjects with …
Baylor Role: Lead Sponsor
Completed
Ability to Cope With Type 1 Diabetes
Coping with type 1 diabetes can be very difficult. Type 1 diabetes is a very unique chronic disease because it requires constant attention to several responsibilities such as daily glucose …
Baylor Role: Lead Sponsor