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Search Clinical Trials
Completed
Multisite Controlled Trial of Cocaine Vaccine (External Link)
This 18-week, placebo-controlled randomized clinical trial among 300 cocaine dependent patients is designed to test the efficacy of a newly developed active vaccine against cocaine (TA-CD). TA-CD vaccine consists of …
Baylor Role:
Lead Sponsor
Completed
Role of HIV on Glutathione Synthesis and Oxidative Stress (External Link)
HIV infection is associated the development of increased oxidative stress and deficiency of glutathione (GSH), the dominant endogenous antioxidant protein, but the underlying mechanisms contributing to GSH deficiency are hitherto …
Baylor Role:
Lead Sponsor
Completed
Intranasal Oxytocin and Maternal Neglect (External Link)
The investigators plan to conduct fMRI scanning with a group of mothers who are blindly and randomly assigned either intranasal oxytocin or a placebo. Aim 1: To determine whether intranasal …
Baylor Role:
Lead Sponsor
Completed
Effect of Exenatide on Liver and Heart Fat and Inflammation (External Link)
Type 2 diabetics and insulin resistant individuals have an excess of fat in the liver which is not attributable to alcohol or other known causes of liver disease, a condition …
Baylor Role:
Lead Sponsor
Completed
NAC as a Potential Treatment for Methamphetamine Dependence (External Link)
N-acetyl-l-cysteine (NAC) treatment is associated with reduced susceptibility to reinstatement of cocaine seeking behavior in rats (Baker et al 2002) and with reduced cue-induced craving in cocaine-dependent human volunteers (LaRowe …
Baylor Role:
Lead Sponsor
Completed
Pharmacogenetics of Doxazosin for Cocaine Dependence (External Link)
The NE system, especially the alpha 1-adrenergic receptor, may play an important role in cocaine addiction in humans. The results of this study will provide medical safety data on the …
Baylor Role:
Lead Sponsor
Completed
The Effects of Doxazosin on the Cardiovascular and Subjective Effects of Cocaine (External Link)
Primary Objective: The primary objective is to determine the safety of treatment with doxazosin in cocaine-dependent volunteers by examining hemodynamic and subjective effects of administration of ascending doses of cocaine …
Baylor Role:
Lead Sponsor
Completed
Carboplatin and Docetaxel Followed by Epstein-Barr Virus Cytotoxic T Lymphocytes (External Link)
A blood sample will be obtained to start making the CTLs before the patient begins chemotherapy. The patients EBV-specific T cells will be grown while the patient is being treated …
Baylor Role:
Lead Sponsor
Completed
Pain After Laparoscopic Cholecystectomy (External Link)
To the investigators' knowledge, no study has looked at differences in postoperative pain when comparing maintenance of anesthesia with isoflurane, desflurane, sevoflurane, and propofol in laparoscopic cholecystectomy. The investigators' hypothesis …
Baylor Role:
Lead Sponsor
Completed
The Efficacy of Doxazosin for Cocaine Users (External Link)
The NE system, especially the alpha 1-adrenergic receptor, may play an important role in cocaine addiction in humans. The results of this study will provide medical safety data on the …
Baylor Role:
Lead Sponsor