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22 Results
Not Yet Recruiting
Tolerability of Enteral NAC in Infants
Biliary atresia (BA), a neonatal liver disease characterized by impaired bile flow, is the most common indication for pediatric liver transplantation. The only identified treatment option other than liver transplant …
Baylor Role: Collaborator
Not Yet Recruiting
Neoadjuvant Durvalumab and Tremelimumab With and Without Chemotherapy for Mesothelioma
Study Design: The study will be a two-arm, randomized non-comparative Phase Ib/IIa study of induction dual immunotherapy with durvalumab/tremelimumab OR platinum chemotherapy (cisplatin or carboplatin) and pemetrexed chemotherapy plus dual …
Baylor Role: Lead Sponsor
Recruiting
Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease
Glutathione (GSH) deficiency, oxidative stress, mitochondrial dysfunction, insulin resistance and inflammation are linked to Alzheimer's disease (AD). In prior studies, investigators have shown that GSH deficiency contributes to mitochondrial impairment …
Baylor Role: Lead Sponsor
Recruiting
Glycine "Deficiency" and the Kinetics of Acylglycine in Morbid Obesity
This study aims to evaluate the effects of oral glycine supplementation on plasma glycine concentration, intracellular glutathione (GSH) concentration, plasma acylglycine concentration, urine acylglycine concentration, and insulin resistance in subjects …
Baylor Role: Collaborator
Active, Not Recruiting
Glutathione, Oxidative Stress and Mitochondrial Function in COVID-19
This study will investigate associated defects in the following two populations of patients with COVID-19: Hospitalized patients admitted for COVID-19 will sign an informed consent form, and be randomized to …
Baylor Role: Lead Sponsor
Completed
N-Acetylcysteine in Biliary Atresia After Kasai Portoenterostomy
Biliary atresia (BA) is a disease characterized by fibro-obliteration of extrahepatic bile ducts leading to impaired bile flow (Sokol et al., 2007). BA is treated with the Kasai portoenterostomy (KP), …
Baylor Role: Lead Sponsor
Recruiting
Glutathione in Mild Cognitive Impairment
Subjects with MCI will be recruited by written informed consent using forms approved by the Baylor IRB. Subjects will stop nonvitamin supplements for 4wks before screening labs (blood count, HbA1c, …
Baylor Role: Lead Sponsor
Terminated
Study of Cytoreductive Surgery and Hyperthermic Intraoperative Chemotherapy With Pemetrexed and Cisplatin for MPM
TREATMENT PLAN PREOPERATIVE HYDRATION According to our observations, preoperative hydration reduces the risk of nephrotoxicity from intrathoracic infusion of hyperthermic cisplatin. Therefore, all patients will be admitted the night before …
Baylor Role: Lead Sponsor
Completed
Energetics and Function in Older Humans
Data not available at present
Baylor Role: Lead Sponsor
Completed
Glutathione and Function in HIV Patients
Detailed data are not as yet available
Baylor Role: Lead Sponsor