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Haploidentical Hematopoietic Cell Transplantation Using TCR Alpha/Beta and CD19 Depletion (External Link)
This is a phase I/II study of haploidentical HCT (HHCT) with ex vivo TCRαβ+ and CD19+ depletion using the CliniMACS device in patients with hematological malignancies and non-malignant disorders. HHCT …
Baylor Role:
Lead Sponsor
Recruiting
Enhancing Psychotherapy for Veterans and Service Members With PTSD and Anxiety (External Link)
Anxiety disorders and posttraumatic stress disorder (PTSD) are among the leading mental health problems in the nation and are highly prevalent among service members and Veterans. The process of recovery …
Baylor Role:
Lead Sponsor
Recruiting
Marfan Syndrome Moderate Exercise Trial II (External Link)
Marfan syndrome (MFS) is a distinctive connective tissue disorder with clinical phenotypes that affect multiple organ systems including the heart, bones, ligaments, and eyes, and are associated with significant risk …
Baylor Role:
Lead Sponsor
Recruiting
CBT Augmentation to Promote Medication Discontinuation in Pediatric OCD (External Link)
Pediatric obsessive-compulsive disorder (OCD) is a common, chronic, and severe psychiatric disorder. Currently, many youth with OCD are treated with medication, such as a serotonin reuptake inhibitor (SRI); however, only …
Baylor Role:
Lead Sponsor
Recruiting
Rett Syndrome Registry (External Link)
The Rett Syndrome Registry is a longitudinal observational study of individuals with MECP2 mutations and a diagnosis of Rett syndrome. Designed together with the IRSF Rett Syndrome Center of Excellence …
Baylor Role:
Collaborator
Recruiting
Oxytocin for Hypermobile Ehlers-Danlos Syndrome (External Link)
This will be a single-site study to evaluate the effect of IV oxytocin on chronic pain in female adult patients with hypermobile EDS. Oxytocin secretion in the body is dynamic …
Baylor Role:
Lead Sponsor
Recruiting
The Rett Syndrome Global Registry (External Link)
The Rett Syndrome Global Registry is a fully remote, global, caregiver-reported registry intended to meet the needs of caregivers, clinicians and researchers, and therapeutic developers with the goal to increase …
Baylor Role:
Collaborator
Recruiting
Evaluating a New Stool Based qPCR for Diagnosis of Tuberculosis in Children and People Living With HIV (External Link)
Tuberculosis (TB) continues to be a leading cause of morbidity and mortality among children and people living with HIV (PLHIV). Despite significant progress in TB diagnostics, improvement of childhood TB …
Baylor Role:
Collaborator
Recruiting
XEN1101 for Major Depressive Disorder (External Link)
This project is designed to examine the neuronal KCNQ2/3 potassium (K+) channel subtype as a novel treatment target for mood disorders through the administration of the KCNQ-selective channel opener XEN1101 …
Baylor Role:
Collaborator
Recruiting
Li-Fraumeni & TP53 (LiFT UP): Understanding and Progress (External Link)
This research study looks to enroll as many people with LFS or TP53 gene variants as possible in order to: - Better estimate cancer risks in individuals with TP53 variants …
Baylor Role:
Collaborator