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Linking Endotypes and Outcomes in Pediatric Acute Respiratory Distress Syndrome (External Link)
Investigators will measure pre-determined biomarkers with known or suspected association with ARDS severity or outcome. Simultaneously, investigators will measure gene expression of peripheral blood. Both plasma biomarkers and gene expression …
Baylor Role:
Collaborator
Active, Not Recruiting
Patch vs. No Patch Fetoscopic Meningomyelocele Repair Study (External Link)
Spina bifida can be a devastating neurological congenital anomaly. It results from incomplete closure of the neural tube between 22 and 28 embryological days. Its incidence is approximately 1-2 per …
Baylor Role:
Lead Sponsor
Active, Not Recruiting
Oral Care in Infants With Gastroschisis (External Link)
Breast milk is recommended for most infants by the American Academy of Pediatrics as there are multiple benefits. However, some infants, such as extremely premature infants, are unable to receive …
Baylor Role:
Lead Sponsor
Active, Not Recruiting
Dental Malocclusion and Craniofacial Development in OI (External Link)
Investigators will look at dental health in people with OI and will describe teeth misalignment and head and neck defects in individuals with moderate to severe Osteogenesis Imperfecta (OI). Investigators …
Baylor Role:
Lead Sponsor
Active, Not Recruiting
Urinary Biomarkers of OI Pathobiology (External Link)
Osteogenesis Imperfecta (OI) is a rare disorder that causes bones to break easily. People with OI may have broken bones with little or no trauma, dentinogenesis imperfecta (DI), and, in …
Baylor Role:
Lead Sponsor
Active, Not Recruiting
Use of Human Milk Cream to Decrease Length of Stay in Extremely Premature Infants (External Link)
The primary hypothesis of the study is that infants who receive an exclusive HM-based diet with the addition of a HM-derived cream caloric (Cream group) will have a shorter length …
Baylor Role:
Lead Sponsor
Active, Not Recruiting
Fetoscopic Meningomyelocele Repair Study (External Link)
Spina bifida can be a devastating neurological congenital anomaly . It results from incomplete closure of the neural tube between 22 and 28 embryological days. Its incidence is approximately 1-2 …
Baylor Role:
Lead Sponsor
Active, Not Recruiting
Phenylbutyrate Therapy for Maple Syrup Urine Disease (External Link)
Maple syrup urine disease is a severe inborn error of amino acid metabolism caused by deficiency of the mitochondrial branched-chain alpha-ketoacid dehydrogenase complex (BCKDC) resulting in the accumulation of branched-chain …
Active, Not Recruiting
Radiation- and Alkylator-free Bone Marrow Transplantation Regimen for Patients With Dyskeratosis Congenita (External Link)
Dyskeratosis congenita (DC) is an inherited multisystem disorder, which classically presents with a clinical triad of skin pigment abnormalities, nail dystrophy, and oral leukoplakia. DC is part of a spectrum …
Baylor Role:
Collaborator
Active, Not Recruiting
Study of Selected X-linked Disorders: Goltz Syndrome (External Link)
Goltz syndrome or Focal Dermal Hypoplasia (FDH) is an X-linked dominant neurodevelopmental disorder. The primary features of FDH include areas of hypoplastic skin (atrophy, linear pigmentation and herniation of fat …
Baylor Role:
Lead Sponsor