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Enrolling By Invitation
Post-operative Pain Management in Children With Supracondylar Humerus Fractures (External Link)
Prior to surgery, participants will be randomly assigned to a group that will determine whether they are prescribed an opioid vs non-opioid pain management plan at discharge. Each participants' parent …
Baylor Role:
Lead Sponsor
Completed
Lemborexant Augmentation of Naltrexone for Alcohol Craving and Sleep (External Link)
Alcohol is one of the most popular substances used worldwide for thousands of years. Globally, harmful alcohol use continues to be a major public health and economic burden. The World …
Baylor Role:
Lead Sponsor
Completed
Complementary Combination Therapy for Cocaine Dependence (External Link)
During a screening session participants will provide buccal swab for genetics testing, as preliminary data shows that effects of cocaine and of doxazosin are impacted significantly by the genotype at …
Baylor Role:
Lead Sponsor
Completed
Pharmacogenetic Trial of Doxazosin for Treatment of Cocaine Abuse (External Link)
The noradrenergic system, especially the alpha 1-adrenergic receptor, may play an important role in cocaine addiction in humans. Doxazosin is a long-acting and selective alpha 1-adrenergic receptor blocker, which inhibits …
Baylor Role:
Collaborator
Terminated
A Pilot Study of Candesartan as a Treatment for Cocaine Dependence (External Link)
The noradrenergic system may play an important role in cocaine addiction in humans. Angiotensin II (Ang II) is known to enhance noradrenergic activity, which contributes to effects on blood pressure …
Baylor Role:
Lead Sponsor
Terminated
A Comparison Trial Between PCA and Epidural Analgesia for Pectus Excavatum Repair (External Link)
Pectus excavatum is a cartilaginous deformity that is the most common congenital anterior chest wall defect in children [1]. Children with this disease process often complain of dyspnea, decreased exercise …
Baylor Role:
Lead Sponsor
Completed
Pramipexole as a Treatment for Cocaine Dependence (External Link)
In this protocol we propose to assess the impact of treatment with higher doses of the potent D2/3 agonist pramipexole, using the extended release preparation that has been shown to …
Baylor Role:
Lead Sponsor
Completed
Exercise as a Behavioral Treatment for Cocaine Dependence (External Link)
This proposal represents an important research effort with considerable public health significance in that it will provide detailed behavioral and physiological data for a non-pharmacological intervention to treat stimulant addiction. …
Baylor Role:
Lead Sponsor
Terminated
Intraoperative Methadone vs Morphine for Postoperative Pain Control in Patients Undergoing Surgery of the Tibia (External Link)
Satisfactory pain control can generally be achieved after major surgery of the tibia through a combination of enteral and parenteral medications, neuraxial techniques (such as epidural analgesia), and/or regional techniques …
Baylor Role:
Lead Sponsor
Completed
A Pilot Study of Cabergoline for the Treatment of Cocaine Dependence (External Link)
Secondary aims are to clarify the genetics of substance abuse, potentially leading to improved methods to diagnosis those at risk and to help develop better therapeutic interventions and to develop …
Baylor Role:
Lead Sponsor