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Terminated
Treatment of Adult Patients With Hemoglobin SC Disease (SCYTHE) (External Link)
Patients will be recruited from the patient population followed at the Texas Children's Cancer and Hematology Centers (TCC/HC)/Baylor College of Medicine (BCM) and the University of Texas Houston Hematology Center. …
Baylor Role:
Lead Sponsor
Terminated
Sertraline in Treatment of Low-Risk Myelodysplastic Syndrome (External Link)
This pilot study investigates clinical benefit of four 28-day cycles of sertraline in low-risk MDS patients. Participants will receive 100mg of oral sertraline daily. The study will also evaluate potential …
Baylor Role:
Collaborator
Terminated
Treatment of Hemoglobin SC Disease With Hydroxyurea (External Link)
To be eligible to participate in this study, patients must have HbSC disease, have experienced a sickle cell disease related complication, or have a score of 80 or lower on …
Baylor Role:
Lead Sponsor
Terminated
Eosinophilic Esophagitis Clinical Therapy Comparison Trial (External Link)
This study is a open label, randomized, prospective clinical trial comparing the efficacy of a topical steroid preparation to an antigen (food) elimination diet. A total of 40 participants will …
Baylor Role:
Lead Sponsor
Terminated
Transcranial Doppler (TCD) With Transfusions Changing to Hydroxyurea (External Link)
Despite the clear results of the STOP and the follow-up STOP II trials, the use of chronic erythrocyte transfusions for primary stroke prevention in children with Sickle Cell Anemia (SCA) …
Baylor Role:
Collaborator
Terminated
T-Reg Cell Kinetics, Stem Cell Transplant, REGALE (External Link)
To participate in this transplant, the patient will need to have a central line. Before the transplant we will test the blood for viruses which can cause problems after the …
Baylor Role:
Lead Sponsor
Terminated
Reduced Intensity Preparative Regimen Followed by Stem Cell Transplant (FAB) (External Link)
Allogeneic stem cell transplantation with high-dose chemotherapy affords a better chance of cure of malignant and non-malignant hematological diseases compared to autologous transplantation, because of the lack of stem cell …
Baylor Role:
Lead Sponsor
Terminated
Steroid Treatment for Sickle Cell Pain Crisis (External Link)
In the United States, 9% of African Americans have sickle cell trait and 1 in 600 has sickle cell disease. Vaso- occlusive crises in sickle cell disease remain a frequent …
Baylor Role:
Lead Sponsor
Terminated
Bone Marrow Transplantation, Hemoglobinopathies, SCALLOP (External Link)
Prior to any bone marrow transplant, we will need patients to: - Answer questions about their medical history; - Undergo a physical examination; - Have tests done to see how …
Baylor Role:
Collaborator
Terminated
Allogeneic Stem Cell Transplantation, Severe Homzygous 0/+Thalassemia or Sever Variants of Beta 0/+ Thalassemia, THALLO (External Link)
To be treated on this study, we will test the blood to check for viruses, including HIV (the virus that causes AIDS). If the HIV test is positive, a transplant …
Baylor Role:
Lead Sponsor