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Completed
Pimavanserin Treatment in TS
Tourette Syndrome is typically treated with drugs that block or reduce the function of dopamine (a brain chemical involved in movement). However, many of these drugs have adverse effects including …
Completed
NMDA Receptor Modulation for Hyperarousal in PTSD
This study aims to provide a rigorous test of functional target engagement and "go/no go" milestones for a subsequent POC trial. Investigator will conduct a parallel-arm, randomized, double-blind, placebo-controlled study …
Baylor Role: Lead Sponsor
Completed
Choices4Health: Intervention to Prevent Substance-exposed Pregnancy
A randomized group design (N = 240) will be used to test the efficacy of the C4H-C and C4H-T interventions relative to Brief Advice (BA) to reduce the risk of …
Baylor Role: Collaborator
Completed
Entolimod, an Adjuvant for Vaccine Augmentation
This is a single-blind (participants are blinded), pilot study with no therapeutic or diagnostic intent and limited drug exposure. The study will be conducted at Baylor College of Medicine in …
Baylor Role: Lead Sponsor
Completed
Effect of Monochromatic Light on Incidence of Emergence Delirium in Children
Emergence delirium/emergence agitation (ED/EA) is a behavioral phenomenon of unclear etiology consisting of short lived behavioral changes that can be both traumatic to families and pose a safety risk to …
Baylor Role: Lead Sponsor
Completed
Study to Treat Major Depressive Disorder With a New Medication
Depressive disorders are among the most disabling medical conditions worldwide and currently available treatments fall short of addressing this large public health burden. Dysfunction within the brain reward system is …
Baylor Role: Collaborator
Completed
Prefrontal Cortical Engagement Through Non-Invasive Brain Stimulation in Schizophrenia
Cognitive deficits are a strong predictor of functional outcome in schizophrenia, yet poorly remediated by current treatments. Disturbances in dorsolateral prefrontal cortex (DLPFC) function underlie core impairments such as in …
Baylor Role: Lead Sponsor
Completed
Efficacy of Audio Recorded Guided Imagery vs Deep Breathing Exercises on Functional Gastrointestinal Pain Disorders
Children managed in primary care with a functional gastrointestinal pain disorder will be recruited and studied for this trial. After participants are deemed eligible, they will complete multiple questionnaires and …
Baylor Role: Lead Sponsor
Completed
Telehealth Depression Treatments for Older Adults
The long-term objective of the proposed study is to improve access to depression treatments for low-income, racially diverse homebound seniors, a population experiencing significant disparities in mental health care due …
Baylor Role: Collaborator
Completed
A Salivary miRNA Diagnostic Test for Autism
The central aim of this project is to validate a panel of expressed microRNA (miRNA) in the saliva of children identified at risk for developing ASD by the MCHAT-R. Further, …
Baylor Role: Collaborator