Search Clinical Trials
Completed
Fetal Hemoglobin Induction Treatment Metformin (External Link)
This is a dose escalation, pilot study for subjects with sickle cell anemia (SCA) disease to determine if metformin has a beneficial effect on the treatment and quality of life …
Baylor Role:
Lead Sponsor
Completed
Automated Fetal Weight Estimation: A Multicenter Validation Using Fractional Limb Volume (External Link)
Ultrasound has been used for over 20 years to estimate fetal weight prior to birth. Sometimes this estimation is not always similar to what the baby actually weighs. In addition …
Baylor Role:
Lead Sponsor
Completed
'TOTAL' (Tracheal Occlusion To Accelerate Lung Growth) Trial (External Link)
This is a multi-center, non-blinded randomized controlled trial in fetuses with isolated moderate CDH, i.e. moderate lung hypoplasia (as determined by prenatal assessment of lung development). It essentially compares fetal …
Baylor Role:
Collaborator
Completed
Effect of Caudal and Penile Block on Hypospadias Repair Complications (External Link)
Hypospadias is a one of the most common genitourinary (GU) malformations, seen in approximately 1 of 250 male live births, characterized by proximal location of the urethral meatus, dorsal hooded …
Baylor Role:
Lead Sponsor
Completed
Fetal 3D Study (Fetal Body Composition and Volumes Study) (External Link)
The NICHD Fetal Growth Study was a multi-site, prospective cohort study designed to establish a standard for normal fetal growth (velocity) and size for gestational age in the U.S. population. …
Baylor Role:
Collaborator
Completed
Posterior Fossa Decompression With or Without Duraplasty for Chiari Type I Malformation With Syringomyelia (External Link)
Participants with Chiari Malformation type I and syringomyelia will be randomized to either have a posterior fossa decompression done with or without duraplasty. The participant will then return to the …
Baylor Role:
Collaborator
Completed
Treatment Alternatives in iSGS (NoAAC PR-02 Study) (External Link)
Idiopathic subglottic stenosis (iSGS) is a rare disease in which the trachea narrows for no known reason. Although uncommon (with an estimated incidence of 1:400,000 persons per year), both the …
Baylor Role:
Collaborator
Completed
Comparative Efficacy of Phenylbutyrate (PBA) vs. Benzoate in Urea Cycle Disorders (External Link)
The investigators will study and compare how effectively sodium phenylbutyrate, sodium benzoate, and a combination of the two, help excrete nitrogen in healthy volunteers. Subject participation will require three, separate, …
Baylor Role:
Lead Sponsor
Completed
Nitric Oxide Supplementation in Argininosuccinic Aciduria (External Link)
The investigators will perform a double blind, randomized, placebo-controlled, crossover study of NO supplementation in ASA patients assessing endothelial function and blood pressure as primary endpoints, and markers of nitric …
Baylor Role:
Lead Sponsor
Completed
Seattle-PAP Bubble Nasal CPAP and Work of Breathing (External Link)
The primary outcome variable is work of breathing (WOB) over a two hour period, estimated from pressure-rate products, which are assessed with 6 Fr (2 mm) catheters placed in the …
Baylor Role:
Collaborator