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Completed
Pimavanserin Treatment in TS (External Link)
Tourette Syndrome is typically treated with drugs that block or reduce the function of dopamine (a brain chemical involved in movement). However, many of these drugs have adverse effects including …
Completed
OHI--Randomized Control Trial to Evaluate Efficacy, Acceptability, and Perception of Benefit of an Innovative Custom AFO (External Link)
The investigators propose a randomized control trial to evaluate long term effects and effectiveness of Moore Balance Brace (MBB) ankle foot orthoses (AFO) in reducing risk of falling in older …
Completed
Mobile Decision Support System for Nurse Management of Neuromodulation Therapy (External Link)
The proposed study will evaluate outcomes for Parkinson's disease (PD) patients who are treated with unilateral deep brain stimulation (DBS); patients who consent to the study will be randomized to …
Baylor Role:
Collaborator
Completed
Continuous Tremor Assessment During Daily Activities (External Link)
The specific aim of this study is to evaluate if tremor severity and quality of life can be improved more using continuous home monitoring along with traditional assessments versus traditional …
Baylor Role:
Collaborator
Completed
Adaptive Portable Essential Tremor Monitor (External Link)
The purpose of this study is to evaluate the utility of a portable motion sensor-based system designed to monitor essential tremor (ET) to better prescribe therapy to minimize symptoms and …
Baylor Role:
Collaborator
Completed
Sleep Abnormalities in Rare Genetic Disorders: AS, RTT, and PW (External Link)
Subjects with AS, RTT or PWS and normal siblings (controls) will be recruited for study participation. Subjects will be recruited from the Rare Disease Clinical Research Network (RDCRN) consortium registries …
Baylor Role:
Lead Sponsor
Completed
MER Versus MRI Guidance DBS in Parkinson's Disease (External Link)
Patients who have been randomized into Group 1 will undergo DBS implantation while awake. On the morning of surgery, the patient will undergo placement of the stereotactic head frame under …
Baylor Role:
Lead Sponsor
Completed
A Trial of Levodopa in Angelman Syndrome (External Link)
Levodopa is a prodrug that "delivers" dopamine to the brain. It is usually given with carbidopa, a peripheral decarboxylase inhibitor, to increase the bioavailability of levodopa. Animal studies have suggested …
Baylor Role:
Collaborator
Completed
Amitiza in Constipation Associated With PD (Parkinson's Disease) (External Link)
Parkinson's disease (PD) affects about one million people in the United States. It is a common neurological condition that is clinically defined by rigidity (muscle stiffness), bradykinesia (slowness of movement) …
Baylor Role:
Lead Sponsor
Completed
Selegiline to Zelapar Switch Study in Parkinson Disease Patients (External Link)
This is an open label, multicenter, 6 week study of the conversion from oral selegiline to orally disintegrating selegiline in PD patients with or without motor fluctuations, and currently taking …
Baylor Role:
Lead Sponsor