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Recruiting
Sickle Cell Clinical Research and Intervention Program (External Link)
The St. Jude Pediatric SCD Program has developed a comprehensive plan of care that spans the ages of 0 to 25, and provides the structure for screening and monitoring disease …
Baylor Role:
Collaborator
Completed
Novel Dose Escalation to Predict Treatment With Hydroxyurea (External Link)
To be eligible to participate in this study, patients must have decided that they want to begin hydroxyurea therapy. Patients choosing to participate in this study will be assigned randomly …
Baylor Role:
Lead Sponsor
Completed
A Phase II Trial of Regadenoson in Sickle Cell Anemia (External Link)
If you are willing to participate in this research study you will be asked to undergo some screening tests and procedures to confirm your eligibility. Many of these tests and …
Baylor Role:
Collaborator
Recruiting
Long-term Outcomes and Vascular Evaluation After Coarctation of the Aorta Treatment (External Link)
Study overview. This cross-sectional prospective observational study of patients with CoA previously treated using one of three treatment modalities assesses if treatment type is associated with differences in vascular function. …
Baylor Role:
Collaborator
Terminated
Randomized Clinical Trial of Early Delivery in Fetal Gastroschisis vs. Routine Care (External Link)
Gastroschisis is a congenital malformation in which abdominal organs protrude through an abdominal wall defect, leading to considerable morbidity and mortality during infancy. In contrast to the second class of …
Baylor Role:
Lead Sponsor
Completed
A Safety Study of NNZ-2566 in Patients With Rett Syndrome (External Link)
Rett Syndrome is a developmental disorder primarily if not exclusively affecting females. The disorder is characterized by apparent normal development in early infancy (6-18 months), followed by a period of …
Baylor Role:
Collaborator
Terminated
Pentoxifylline Therapy in Biliary Atresia (External Link)
Biliary atresia (BA) is a devastating liver disease of infancy of unknown etiology, characterized by bile duct obstruction, live fibrosis, and cirrhosis. BA has no known medical treatments. The only …
Baylor Role:
Lead Sponsor
Active, Not Recruiting
Phenylbutyrate Therapy for Maple Syrup Urine Disease (External Link)
Maple syrup urine disease is a severe inborn error of amino acid metabolism caused by deficiency of the mitochondrial branched-chain alpha-ketoacid dehydrogenase complex (BCKDC) resulting in the accumulation of branched-chain …
Completed
Nitric Oxide Flux and Ureagenesis in Argininosuccinate Synthetase Deficiency (ASSD)(Citrullinemia I) (External Link)
This is an interventional, case control study to investigate the production of nitric oxide in patients with citrullinemia type I. Through the infusion of isotopes [15N2-ureido] arginine, [5-13C,4, 4, 5, …
Baylor Role:
Lead Sponsor
Terminated
A Comparison Trial Between PCA and Epidural Analgesia for Pectus Excavatum Repair (External Link)
Pectus excavatum is a cartilaginous deformity that is the most common congenital anterior chest wall defect in children [1]. Children with this disease process often complain of dyspnea, decreased exercise …
Baylor Role:
Lead Sponsor