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Allogeneic Tumor Cell Vaccination With Oral Metronomic Cytoxan in Patients With High-Risk Neuroblastoma
WHAT IS THE OVERALL TREATMENT PLAN AND HOW MANY VACCINATIONS WILL THE PATIENT RECEIVE? There will be several injections of the vaccine scheduled. The first injection will be given 3 …
Baylor Role: Lead Sponsor
Completed
Modafinil - Escitalopram Study for Cocaine Dependence
In this application, we propose an augmentation strategy intended to improve the efficacy of modafinil as a potential treatment for cocaine dependence. Recent data indicates that during chronic treatment modafinil …
Baylor Role: Lead Sponsor
Completed
Multisite Controlled Trial of Cocaine Vaccine
This 18-week, placebo-controlled randomized clinical trial among 300 cocaine dependent patients is designed to test the efficacy of a newly developed active vaccine against cocaine (TA-CD). TA-CD vaccine consists of …
Baylor Role: Lead Sponsor
Completed
Role of HIV on Glutathione Synthesis and Oxidative Stress
HIV infection is associated the development of increased oxidative stress and deficiency of glutathione (GSH), the dominant endogenous antioxidant protein, but the underlying mechanisms contributing to GSH deficiency are hitherto …
Baylor Role: Lead Sponsor
Completed
Effect of Exenatide on Liver and Heart Fat and Inflammation
Type 2 diabetics and insulin resistant individuals have an excess of fat in the liver which is not attributable to alcohol or other known causes of liver disease, a condition …
Baylor Role: Lead Sponsor
Completed
NAC as a Potential Treatment for Methamphetamine Dependence
N-acetyl-l-cysteine (NAC) treatment is associated with reduced susceptibility to reinstatement of cocaine seeking behavior in rats (Baker et al 2002) and with reduced cue-induced craving in cocaine-dependent human volunteers (LaRowe …
Baylor Role: Lead Sponsor
Completed
Pharmacogenetics of Doxazosin for Cocaine Dependence
The NE system, especially the alpha 1-adrenergic receptor, may play an important role in cocaine addiction in humans. The results of this study will provide medical safety data on the …
Baylor Role: Lead Sponsor
Active, Not Recruiting
Her2 Chimeric Antigen Receptor Expressing T Cells in Advanced Sarcoma
Because the cells have a new gene in them the patient will be followed for a total of 15 years to see if there are any long term side effects …
Baylor Role: Lead Sponsor
Withdrawn
RTI-336 as a Treatment for Methamphetamine Dependence
Methamphetamine (METH) is a highly addictive stimulant and acute exposure causes dopamine (DA) release and stimulates midbrain reward centers. The proposed work represents an important research effort with considerable public …
Baylor Role: Lead Sponsor
Completed
The Effects of Doxazosin on the Cardiovascular and Subjective Effects of Cocaine
Primary Objective: The primary objective is to determine the safety of treatment with doxazosin in cocaine-dependent volunteers by examining hemodynamic and subjective effects of administration of ascending doses of cocaine …
Baylor Role: Lead Sponsor