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26 Results
Recruiting
Deep Brain Stimulation (DBS) for Depression Using Directional Current Steering and Individualized Network Targeting
Treatment-resistant depression (TRD) is a major worldwide burden. Major depression has a lifetime prevalence of ~15% across developed countries. Up to a third of patients fail to respond adequately to …
Baylor Role: Lead Sponsor
Recruiting
Preventing Persistent Post-Surgical Pain and Dysfunction
Persistent post-surgical pain (PPSP) is a common and debilitating problem following surgery.1 Orthopedic surgeries, such as Total Knee Arthoplasty (TKA), are consistently associated with high postoperative pain, putting patients at …
Baylor Role: Collaborator
Completed
Peer-led Group Intervention for Coping With Disaster
Approximately 20% of individuals have significant behavioral health concerns. Exposure to a disaster like Hurricane Harvey and its aftermath often exacerbates pre-existing issues and/or brings new issues, with post-traumatic stress …
Baylor Role: Lead Sponsor
Completed
Maternal Mental Health in the Hospital Setting
Study participants will complete a survey about their general needs and access to resources and a survey to screen for postpartum depression to determine if the participant will be enrolled. …
Completed
Study to Treat Major Depressive Disorder With a New Medication
Depressive disorders are among the most disabling medical conditions worldwide and currently available treatments fall short of addressing this large public health burden. Dysfunction within the brain reward system is …
Baylor Role: Collaborator
Completed
Telehealth Depression Treatments for Older Adults
The long-term objective of the proposed study is to improve access to depression treatments for low-income, racially diverse homebound seniors, a population experiencing significant disparities in mental health care due …
Baylor Role: Collaborator
Completed
Aggression Prevention Training for Caregivers of Persons With Dementia (APT)
Eighty percent of PWD have behavioral or psychological disturbances, including 40% that are aggressive behaviors. The prevalence of pain in PWD is about 60%, and it is a strong predictor …
Baylor Role: Lead Sponsor
Completed
Double-Blind, Placebo-Controlled Trial of Ketamine Therapy in Treatment-Resistant Depression (TRD)
The primary objective is to investigate whether all doses (0.1 mg/kg, 0.2 mg/kg, 0.5 mg/kg, and 1.0 mg/kg) of ketamine are superior to active placebo (midazolam 0.045 mg/kg) therapy in …
Baylor Role: Collaborator
Completed
One-Day Intervention for Depression and Impairment in Migraine Patients
Adults with comorbid depression and migraine will be randomized to a 1-day (6-hour) workshop of Acceptance and Commitment Training + Migraine Education (ACT-ME) or Migraine Education only (MEO). The intervention …
Baylor Role: Lead Sponsor
Active, Not Recruiting
DBS of the Lateral Habenula in Treatment-Resistant Depression
This research study includes the following parts: 1. medical, psychiatric, and cognitive evaluations 2. implantation of the brain stimulation system, and 3. follow up including programming and psychiatric testing after …