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10 Results
Not Yet Recruiting
RIC-NEC Randomized Controlled Trial
Background: Necrotizing enterocolitis (NEC) is a serious intestinal disease of preterm and term neonates which remains a major cause of intestinal failure, and an unsolved clinical challenge in pediatrics resulting …
Baylor Role: Collaborator
Recruiting
Early Predictors of Necrotizing Enterocolitis in Neonates
The study will enroll premature, low birth weight infants in the Neonatal Intensive Care Units (NICU). Potential study subjects will be identified upon delivery, or transfer to the NICU, and …
Baylor Role: Lead Sponsor
Withdrawn
Addition of Lactobacillus to Metronidazole in Treatment of CDAD
Clostridium difficile associated disease (CDAD), which nearly always follows antibiotic therapy, has become increasingly common and important in American hospitals, causing substantial morbidity and mortality. Metronidazole is the recommended treatment …
Baylor Role: Collaborator
Active, Not Recruiting
A Biologic Validation of Biomarkers of Progressive NEC & Sepsis
Necrotizing enterocolitis (NEC) is a severe, sometimes life-threatening inflammation of the intestine that occurs most often in premature babies. If it progresses, the wall of the intestine may perforate, spilling …
Baylor Role: Collaborator
Completed
Vancomycin vs. Nitazoxanide to Treat Recurrent C. Difficile Colitis
Clostridium difficile is the leading cause of nosocomial diarrheal disease associated with antibiotic therapy. This is a debilitating condition with substantial morbidity and a mortality that used to be said …
Baylor Role: Collaborator
Completed
Fecal Bacterial Flora in Clostridium Difficile-Associated Diarrhea
Clostridium difficile associated colitis is an increasing problem in hospitals throughout the developed world; the number of cases has increased, and the failure to respond to conventional therapy has become …
Baylor Role: Collaborator
Completed
Response of Clostridium Difficile Infection to Metronidazole Therapy
Clostridium difficile is a major cause of nosocomial infection. When this organism proliferates in the colon, usually as a result of prior antibiotic therapy in a hospitalized or otherwise debilitated …
Baylor Role: Collaborator
Completed
Association Between Response to Treatment of C. Diff Colitis and Anti-C.Diff Toxin Antibody
Clostridium difficile is the leading cause of nosocomial diarrheal disease associated with antibiotic therapy. This is a debilitating condition with substantial morbidity and mortality that may be around 2-3%. Current …
Baylor Role: Collaborator
Completed
Compassionate Use of Nitazoxanide for the Treatment of Clostridium Difficile Infection
Clostridium difficile is the leading cause of nosocomial diarrheal disease associated with antibiotic therapy. This is a debilitating condition with substantial morbidity and a mortality that may be around 2-3%. …
Baylor Role: Collaborator
Completed
Study of the Relationship Between Feeding and Late Onset Sepsis and/or Necrotizing Enterocolitis in Low Birth Weight Infants
PROTOCOL OUTLINE: This is a randomized, double blind study in arms I and II. Patients are randomized to receive either fortified pasteurized donor human milk (arm I) or preterm formula …
Baylor Role: Collaborator