A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.

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Prevent Hepatocellular Carcinoma Through Screening, Vaccination, and Treatment of Viral Hepatitis
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Department of Medicine Grand Rounds
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Hepatology and Liver Transplantation Grand Rounds
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