Suicidal Recovery Predicted by MicroRNAS as Epigenetic Plasma Biomarkers
* You will be redirected to the BCM DCPD credit management site when claiming credit and may be asked to register or log in.
In this presentation, Dr. Thomas Kosten discusses his research on the role of biomarkers, specifically epigenetic microRNAs, in suicidality and recovery from attempted suicide. He describes patterns in blood and brain gene expression found in study subjects who have completed suicide and proposes future research directions and potential screening tools to improve health outcomes for high-risk patients.
This Menninger Department of Psychiatry and Behavioral Sciences Grand Rounds session took place on March 6, 2024 at 12:00 p.m.
Activity Information
How to Claim Credit
You may claim credit after watching this activity.
You will be redirected to the BCM DCPD credit management site when claiming credit and may be asked to register or log in.
Needs Statement
Psychiatrists, psychologists, psychiatric nurses, social workers, and healthcare professionals in related disciplines need to receive regular updates on advances in neuroscience, psychiatric research, psychotherapy, and the evolving best practices for evaluating, diagnosing, and treating psychiatric disorders. The series aims to improve clinical practice through critical appraisal of psychiatric research, the use of evidence-based treatment approaches, and the integration of multiple treatment modalities to enhance the quality of psychiatric care and improve patient outcomes.
Educational Objectives
At the conclusion of the session, the participants should be able to:
- Review the multiple factors associated with suicidality including genetics interacting with psychiatric and behavioral disorders.
- Discuss how epigenetic microRNAs (miRNA) can provide integrated and rapid gene regulation relevant to predicting risk and recovery from suicidality and how these changes in miRNA levels can be tracked in blood samples.
- Recognize significant changes in blood levels of microRNAs as biomarkers for recovery from suicidality during hospitalization.
- Describe how neurobiology may lag behind verbal statements of “not feeling suicidal” and identify “accident prone” individuals at high risk for serious suicide attempts.
Target Audience
Professional Categories
- Physicians
- Medical Students
- Fellows
- Nurses
- Other Health Professionals
Specialties
- Psychiatry
Interest Groups
Activity Evaluation
Evaluation by questionnaire will address program content, presentation, and possible bias.
Educational Methods
- Lectures
Accreditation/Credit Designation
Baylor College of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Baylor College of Medicine designates this enduring material activity for a maximum of 1 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Social Work: The Baylor College of Medicine Division of Continuing Professional Development (License Number 7270) is an approved continuing education provider for Social Workers through the Texas State Board of Social Worker Examiners. This activity has been approved for 1 continuing education unit.
Activity Director
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Kim-Lan Tran Czelusta, M.D.
Vice Chair for Education, Brown Foundation Chair in Psychiatric Education in the Department of Psychiatry and Behavioral Sciences
Baylor College of Medicine
Term of Approval
March 1, 2024 through March 31, 2026. Original release date: March 1, 2024.
Disclosure Policy
Baylor College of Medicine (BCM) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education (CME) for physicians. BCM is committed to sponsoring CE activities that are scientifically based, accurate, current, and objectively presented.
In accordance with the ACCME Standards for Commercial Support, BCM has implemented a mechanism requiring everyone in a position to control the content of an educational activity (i.e., directors, planning committee members, faculty) to disclose any relevant financial relationships with commercial interests (drug/device companies) and manage/resolve any conflicts of interest prior to the activity. Individuals must disclose to participants the existence or non-existence of financial relationships at the time of the activity or within 24 months prior.
In addition, BCM has requested activity faculty/presenters to disclose to participants any unlabeled use or investigational use of pharmaceutical/device products; to use scientific or generic names (not trade names) in referring to products; and, if necessary to use a trade name, to use the names of similar products or those within a class. Faculty/presenters have also been requested to adhere to the ACCME's validation of clinical content statements.
BCM does not view the existence of financial relationships with commercial interests as implying bias or decreasing the value of a presentation. It is up to participants to determine whether the relationships influence the activity faculty with regard to exposition or conclusions. If at any time during this activity you feel that there has been commercial/promotional bias, notify the Activity Director or Activity Coordinator. Please answer the questions about balance and objectivity in the activity evaluation candidly.
All of the relevant financial relationships listed for these individuals have been mitigated.
Swann AC, Graham DP, Wilkinson AV, Kosten TR. Suicide Risk in a National VA Sample: Roles of Psychiatric Diagnosis, Behavior Regulation, Substance Use, and Smoking. J Clin Psychiatry. 2022;83(3):21m14123. Published 2022 Jun 6. doi:10.4088/JCP.21m14123
Mamdani F, Weber MD, Bunney B, et al. Identification of potential blood biomarkers associated with suicide in major depressive disorder. Translational Psychiatry. 2022;12(1). doi:10.1038/s41398-022-01918-w
Bader AG, Brown D, Winkler M. The promise of MicroRNA replacement therapy. Cancer Research. 2010;70(18):7027-7030. doi:10.1158/0008-5472.can-10-2010
Rederstorff M. Small Non-Coding RNAS: Methods and Protocols. Springer; 2022.
Rufino KA, Beyene H, Poa E, Boland RJ, Patriquin MA. A false sense of security: Rapid improvement as a red flag for death by suicide. Journal of Consulting and Clinical Psychology. 2022;90(5):405-412. doi:10.1037/ccp0000723
Nielsen DA, Deng H, Patriquin MA, et al. Association of TPH1 and serotonin transporter genotypes with treatment response for SUICIDAL IDEATION: A preliminary study. European Archives of Psychiatry and Clinical Neuroscience. 2019;270(5):633-642. doi:10.1007/s00406-019-01009-w
Capuzzi E, Caldiroli A, Capellazzi M, Tagliabue I, Buoli M, Clerici M. Biomarkers of suicidal behaviors: A comprehensive critical review. Adv Clin Chem. 2020;96:179-216. doi:10.1016/bs.acc.2019.11.005
Smalheiser NR, Lugli G, Rizavi HS, Torvik VI, Turecki G, Dwivedi Y. MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects. PLoS One. 2012;7(3):e33201. doi:10.1371/journal.pone.0033201
Disclosures
The following individual(s) has/have reported financial or other relationship(s) with commercial entities whose products/services may relate to the educational content of this activity:
Presenter
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Thomas Kosten, M.D., M.A.
Jay H. Waggoner Endowed Chair, Professor
Baylor College of Medicine
Disclosure:
- Consultancy: Relmada
Activity Director
-
Kim-Lan Tran Czelusta, M.D.
Vice Chair for Education, Brown Foundation Chair in Psychiatric Education in the Department of Psychiatry and Behavioral Sciences
Baylor College of Medicine
Disclosure:
Nothing to disclose.
Planning Committee Members
-
Kim-Lan Tran Czelusta, M.D.
Vice Chair for Education, Brown Foundation Chair in Psychiatric Education in the Department of Psychiatry and Behavioral Sciences
Baylor College of Medicine
Disclosure:
Nothing to disclose.
-
Mauro A. Garcia-Altieri, M.D.
Assistant Professor
Baylor College of Medicine
Disclosure:
Nothing to disclose.
-
Jennifer R. Gatchel, M.D., Ph.D.
Associate Professor
Baylor College of Medicine, Michael E. DeBakey VA Medical Center
Disclosure:
Nothing to disclose.
-
-
Ashley W. LeMaire, Ph.D.
Assistant Professor
Baylor College of Medicine, Menninger Clinic
Disclosure:
Nothing to disclose.
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Adeolu O. Oladunjoye, M.B.Ch.B., M.P.H.
Psychiatry and Behavioral Sciences Resident
Baylor College of Medicine
Disclosure:
Nothing to disclose.
-
Patrick O'Malley, M.D.
Assistant Professor
Baylor College of Medicine, Texas Children's Hospital
Disclosure:
Nothing to disclose.
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Lindsey S. Pershern, M.D.
Associate Professor of Psychiatry and Behavioral Sciences
Baylor College of Medicine
Disclosure:
Nothing to disclose.
-
Jose Ribas Roca, M.D.
Assistant Professor
Baylor College of Medicine
Disclosure:
Nothing to disclose.
-
Shelley Rote, M.D.
Psychiatry and Behavioral Sciences Resident
Baylor College of Medicine
Disclosure:
Nothing to disclose.
-
Kerala Ria Saugh, M.D.
Child and Adolescent Psychiatry Fellow
Baylor College of Medicine
Disclosure:
Nothing to disclose.
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John Saunders, M.D., M.S.
Associate Professor
Baylor College of Medicine
Disclosure:
Nothing to disclose.
-
Asim A. Shah, M.D.
Barbara & Corbin Robertson Jr. Endowed Chair in Psychiatry
Baylor College of Medicine
Disclosure:
Nothing to disclose.
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Daryl Shorter, M.D.
Associate Professor, Medical Director of Addiction Services
Baylor College of Medicine
Disclosure:
Nothing to disclose.
Health Topics
Presenter: