Pediatric Hematology-Oncology Research Seminar Series (September 26, 2024)

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This Pediatric Hematology-Oncology Research Seminar Series session will take place on Thursday, September 26, 2024 at 8:00 a.m. This series is restricted to seminar participants and will not be broadcast.

Activity Information

Needs Statement

Clinical and research faculty, graduate and medical students, clinical and postdoctoral fellows, and clinical and research nurses in pediatric hematology-oncology need to receive regular updates on the latest clinical trial data concerning hematological-oncological disorders in children and advances in targeted therapies for these disorders. Learners also need regular reviews of the ethical and legal issues surrounding end-of-life care and of the evolving practice standards for follow-up care for long-term survivors of hematological-oncological disorders. The series aims to increase the knowledge and improve the skills of the learners to enhance the quality of healthcare, increase patient safety, and improve patient outcomes.

Educational Objectives

At the conclusion of the session, the participants should be able to:

  • Explain the fundamental principles of CRISPR-Cas genome editing and describe how these tools can be applied to modify T cells, enhancing the efficacy and safety of CAR-T in cancer treatment.
  • Learn how to combine genome editing and CAR-T cell therapies with other treatments, such as small molecule inhibitors, to create synergistic anti-tumor strategies that enhance therapeutic outcomes in both hematological malignancies and solid tumors.
  • Critically assess the latest advancements in non-viral gene editing techniques for developing allogeneic, off-the-shelf cell therapies, focusing on strategies to enhance immune compatibility and durability of the therapeutic cells.

Target Audience

Professional Categories

  • Physicians
  • Medical Students
  • Fellows
  • Residents
  • Nurses

Specialties

  • Hematology
  • Oncology
  • Pediatrics

Interest Groups

  • Hospital Medicine

Accreditation/Credit Designation

Baylor College of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Baylor College of Medicine designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Activity Directors

  1. Jonathan Flanagan, Ph.D.

    Jonathan Flanagan, Ph.D.

    Assistant Professor
    Baylor College of Medicine
  2. Michele Redell, M.D., Ph.D.

    Michele Redell, M.D., Ph.D.

    Assistant Professor
    Baylor College of Medicine

Disclosure Policy

Baylor College of Medicine (BCM) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education (CME) for physicians. BCM is committed to sponsoring CE activities that are scientifically based, accurate, current, and objectively presented.

In accordance with the ACCME Standards for Commercial Support, BCM has implemented a mechanism requiring everyone in a position to control the content of an educational activity (i.e., directors, planning committee members, faculty) to disclose any relevant financial relationships with commercial interests (drug/device companies) and manage/resolve any conflicts of interest prior to the activity. Individuals must disclose to participants the existence or non-existence of financial relationships at the time of the activity or within 24 months prior.

In addition, BCM has requested activity faculty/presenters to disclose to participants any unlabeled use or investigational use of pharmaceutical/device products; to use scientific or generic names (not trade names) in referring to products; and, if necessary to use a trade name, to use the names of similar products or those within a class. Faculty/presenters have also been requested to adhere to the ACCME's validation of clinical content statements.

BCM does not view the existence of financial relationships with commercial interests as implying bias or decreasing the value of a presentation. It is up to participants to determine whether the relationships influence the activity faculty with regard to exposition or conclusions. If at any time during this activity you feel that there has been commercial/promotional bias, notify the Activity Director or Activity Coordinator. Please answer the questions about balance and objectivity in the activity evaluation candidly.

All of the relevant financial relationships listed for these individuals have been mitigated.

Disclosures

The following individual(s) has/have reported financial or other relationship(s) with commercial entities whose products/services may relate to the educational content of this activity:

Presenter

  1. Dimitrios Wagner, M.D., Ph.D.

    Dimitrios Wagner, M.D., Ph.D.

    Assistant Professor, Center for Gene Therapy
    Baylor College of Medicine

    Disclosure:
    • Employment (with a commercial interest): Charité - Universitätsmedizin Berlin, Germany (a University Hospital, Physician/ Group Leader)
    • Research Support: Integrated DNA Technologies Inc (free reagents); Genscript (free reagents) (ended)
    • Intellectual Property (patent rights, royalty payments): Multiple Patents in Cell and Gene Therapy space (in particular patent applications that use gene editing for immune cell therapies)

Activity Directors

  1. Jonathan Flanagan, Ph.D.

    Jonathan Flanagan, Ph.D.

    Assistant Professor
    Baylor College of Medicine

    Disclosure:

    Nothing to disclose.

  2. Michele Redell, M.D., Ph.D.

    Michele Redell, M.D., Ph.D.

    Assistant Professor
    Baylor College of Medicine

    Disclosure:

    Nothing to disclose.

Planning Committee Members

  1. Jonathan Flanagan, Ph.D.

    Jonathan Flanagan, Ph.D.

    Assistant Professor
    Baylor College of Medicine

    Disclosure:

    Nothing to disclose.

  2. YoungNa Lee-Kim, M.D. Placeholder Image

    YoungNa Lee-Kim, M.D.

    Associate Professor
    Baylor College of Medicine

    Disclosure:
    • Advisory Committee Membership: Sanofi
  3. Donald Williams Parsons, M.D., Ph.D.

    Donald Williams Parsons, M.D., Ph.D.

    Associate Professor
    Baylor College of Medicine

    Disclosure:

    Nothing to disclose.

  4. Michele Redell, M.D., Ph.D.

    Michele Redell, M.D., Ph.D.

    Assistant Professor
    Baylor College of Medicine

    Disclosure:

    Nothing to disclose.

Presenter:

Dimitrios Wagner, M.D., Ph.D.

Dimitrios Wagner, M.D., Ph.D.

Assistant Professor, Center for Gene Therapy Baylor College of Medicine

Health Topics

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