Obstetrics & Gynecology Grand Rounds (April 3, 2024)

Needs Statement

Physicians, fellows, residents, medical students, and other healthcare professionals need to receive regular updates on practice guidelines, the latest scientific advances, and translational efforts in the field of Obstetrics and Gynecology. The series aims to increase the knowledge and skills of the learners in select topic areas to improve the diagnosis, treatment, and management of obstetric and gynecologic disorders. The series will also address unique ethical challenges in the field.

Educational Objectives

Nonhormonal Treatment of Endometriosis Through Selective Targeting of CSF1R and KIT with Pexidartinib

At the conclusion of the session, the participants should be able to:

• Describe endometriosis prevalence, management strategies, and the need for additional therapeutic options.
• Review receptor tyrosine kinase’s role in targeted therapeutics and the potential opportunity of CSF1R and KIT inhibition in endometriosis.
• Assess the effects of pexidartinib inhibition of CSF1R and KIT in an endometriosis cell model.

Gm614: A Novel X-Linked Gene Associated with Male Factor Infertility in Mice

At the conclusion of the session, the participants should be able to:

• Discuss the background of the Gm614 knockout mouse project.
• Review specific aims for each experiment done to characterize Gm614.
• Recognize experiments currently ongoing with respect to the Gm614 knockout mouse project.
• Summarize findings and discuss the clinical impact of the research project.

Target Audience

Activity Evaluation

Evaluation by questionnaire will address program content, presentation, and possible bias.

Educational Methods

• Lectures
• Case Presentations

Accreditation/Credit Designation

Baylor College of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Baylor College of Medicine designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Term of Approval

April 1, 2024 through April 30, 2026. Original release date: April 1, 2024.

Disclosure Policy

Baylor College of Medicine (BCM) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education (CME) for physicians. BCM is committed to sponsoring CE activities that are scientifically based, accurate, current, and objectively presented.

In accordance with the ACCME Standards for Commercial Support, BCM has implemented a mechanism requiring everyone in a position to control the content of an educational activity (i.e., directors, planning committee members, faculty) to disclose any relevant financial relationships with commercial interests (drug/device companies) and manage/resolve any conflicts of interest prior to the activity. Individuals must disclose to participants the existence or non-existence of financial relationships at the time of the activity or within 24 months prior.

In addition, BCM has requested activity faculty/presenters to disclose to participants any unlabeled use or investigational use of pharmaceutical/device products; to use scientific or generic names (not trade names) in referring to products; and, if necessary to use a trade name, to use the names of similar products or those within a class. Faculty/presenters have also been requested to adhere to the ACCME's validation of clinical content statements.

BCM does not view the existence of financial relationships with commercial interests as implying bias or decreasing the value of a presentation. It is up to participants to determine whether the relationships influence the activity faculty with regard to exposition or conclusions. If at any time during this activity you feel that there has been commercial/promotional bias, notify the Activity Director or Activity Coordinator. Please answer the questions about balance and objectivity in the activity evaluation candidly.

All of the relevant financial relationships listed for these individuals have been mitigated.