The Mouse Metabolism and Phenotyping Core at Baylor College of Medicine

Needs Statement

Physicians, fellows, residents, physician assistants, nurse practitioners, nurses, and other healthcare professionals need to receive regular updates on professional guidelines, advances in basic science and clinical research, and emerging treatment modalities and management strategies for patients with endocrine disorders. The series will explore new models of multidisciplinary care in the field, especially as it relates to patients with cardiometabolic diseases such as obesity and diabetes. The series aims to expand the knowledge of learners, promote adherence to evidence-based guidelines, enhance the quality of endocrinology care, disseminate best clinical practices, and improve patient outcomes.

Educational Objectives

At the conclusion of the session, the participants should be able to:

• Explain why animal models are often used for scientific research related to diabetes and metabolic disorders.
• Discuss equipment and techniques available for the cost-effective characterization of genetic and non-genetic (e.g., diet, pharmacologic interventions) mouse models to investigate the pathogenesis, treatment, and prevention of diabetes and disorders of metabolism.
• Describe the use of insulin clamps in mouse models, the gold standard technique for demonstrating insulin sensitivity and glucose homeostasis in preclinical studies.
• Identify appropriate assays to analyze mitochondrial biogenesis dysfunction in detail using an enhanced metabolic assay platform.

Target Audience

Activity Evaluation

Evaluation by questionnaire will address program content, presentation, and possible bias.

Educational Methods

• Lectures
• Case Presentations
• Literature Review
• Panel Discussion

Accreditation/Credit Designation

Baylor College of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Baylor College of Medicine designates this enduring material activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Term of Approval

March 1, 2024 through March 31, 2026. Original release date: March 1, 2024.

Disclosure Policy

Baylor College of Medicine (BCM) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education (CME) for physicians. BCM is committed to sponsoring CE activities that are scientifically based, accurate, current, and objectively presented.

In accordance with the ACCME Standards for Commercial Support, BCM has implemented a mechanism requiring everyone in a position to control the content of an educational activity (i.e., directors, planning committee members, faculty) to disclose any relevant financial relationships with commercial interests (drug/device companies) and manage/resolve any conflicts of interest prior to the activity. Individuals must disclose to participants the existence or non-existence of financial relationships at the time of the activity or within 24 months prior.

In addition, BCM has requested activity faculty/presenters to disclose to participants any unlabeled use or investigational use of pharmaceutical/device products; to use scientific or generic names (not trade names) in referring to products; and, if necessary to use a trade name, to use the names of similar products or those within a class. Faculty/presenters have also been requested to adhere to the ACCME's validation of clinical content statements.

BCM does not view the existence of financial relationships with commercial interests as implying bias or decreasing the value of a presentation. It is up to participants to determine whether the relationships influence the activity faculty with regard to exposition or conclusions. If at any time during this activity you feel that there has been commercial/promotional bias, notify the Activity Director or Activity Coordinator. Please answer the questions about balance and objectivity in the activity evaluation candidly.

All of the relevant financial relationships listed for these individuals have been mitigated.