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Addressing Caregiver Wellbeing and Improving Child Development (External Link)
The study aim is to implement a bundle of neurodevelopmental interventions and employ an intergenerational care model, focused on the needs of young children and their parents to maximize health …
Baylor Role:
Lead Sponsor
Recruiting
A Single-Session Intervention for Adolescents and Young Adults With Internalizing Problems (External Link)
The mental health of adolescents and young adults (AYA) has greatly been impacted since the beginning of the pandemic. With the increasing number of AYA experiencing depression and anxiety, paired …
Baylor Role:
Lead Sponsor
Recruiting
Transdiagnostic Behavioral Therapy for Anxiety and Depression in Autistic Adolescents (External Link)
About 1 in 54 adolescents are estimated to be on the autism spectrum, with over half suffering from anxiety or depressive disorders. These disorders contribute to suicidality, family stress, social …
Baylor Role:
Lead Sponsor
Recruiting
Rett Syndrome Registry (External Link)
The Rett Syndrome Registry is a longitudinal observational study of individuals with MECP2 mutations and a diagnosis of Rett syndrome. Designed together with the IRSF Rett Syndrome Center of Excellence …
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Functional Connectivity Alterations in Suicidal Patients Among Opioid Users (External Link)
The OFC is functionally connected to other cortical brain regions (e.g., prefrontal and parietal cortices) but also subcortical areas in the dorsal striatum, a core reward circuitry region. The functional …
Baylor Role:
Lead Sponsor
Recruiting
Integrated Tele-Behavioral Activation and Fall Prevention for Low-income Homebound Seniors With Depression (External Link)
Depression and falls are significantly higher in low-income, racially diverse homebound seniors than in the general older-adult population; however, the existing systems of care are not equipped to address disparities …
Baylor Role:
Collaborator
Recruiting
XEN1101 for Major Depressive Disorder (External Link)
This project is designed to examine the neuronal KCNQ2/3 potassium (K+) channel subtype as a novel treatment target for mood disorders through the administration of the KCNQ-selective channel opener XEN1101 …
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Collaborator
Recruiting
Effectiveness of an Integrated Treatment to Address Smoking Cessation and Anxiety/ Depression in People Living With HIV (External Link)
Although the prevalence of smoking has declined over the past 50 years, large disparities in tobacco use remain across several subgroups, particularly disadvantaged and health compromised populations. In fact, the …
Baylor Role:
Collaborator
Recruiting
Deep Brain Stimulation (DBS) for Depression Using Directional Current Steering and Individualized Network Targeting (External Link)
Treatment-resistant depression (TRD) is a major worldwide burden. Major depression has a lifetime prevalence of ~15% across developed countries. Up to a third of patients fail to respond adequately to …
Baylor Role:
Lead Sponsor
Recruiting
Preventing Persistent Post-Surgical Pain and Dysfunction (External Link)
Persistent post-surgical pain (PPSP) is a common and debilitating problem following surgery.1 Orthopedic surgeries, such as Total Knee Arthoplasty (TKA), are consistently associated with high postoperative pain, putting patients at …
Baylor Role:
Collaborator