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18 Results
Not Yet Recruiting
Microbiome Alterations With Xylitol (MAX) in Pregnancy
After consenting to the study, pregnant participants who have a singleton gestation and are <20 weeks' gestation will be randomised into either the intervention arm ( 6.36grams of daily xylitol; …
Baylor Role: Lead Sponsor
Recruiting
Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease
Glutathione (GSH) deficiency, oxidative stress, mitochondrial dysfunction, insulin resistance and inflammation are linked to Alzheimer's disease (AD). In prior studies, investigators have shown that GSH deficiency contributes to mitochondrial impairment …
Baylor Role: Lead Sponsor
Recruiting
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis
Approximately 5,000 children die from septic shock each year in the United States (US); thousands more die worldwide. Most children admitted with sepsis receive initial resuscitation in an emergency department …
Baylor Role: Collaborator
Completed
Genotype-Informed Versus Empiric Management of VirEmia
Background and rationale: Children and adolescents living with HIV and receiving antiretroviral therapy (ART) suffer high rates of treatment failure, predominantly caused by suboptimal adherence to therapy and/or viral drug …
Completed
Cytokine Persistence as a Marker of Inflammation in the at Risk, Low Socioeconomic Status Pediatric Population
Obstructive sleep apnea (OSA) is a common multisystem disorder, affecting up to 10% of the pediatric population. There is scant data about OSA and adenotonsillectomy (AT) outcomes in the very …
Baylor Role: Lead Sponsor
Recruiting
Assessment of Heparin Binding Protein for the Prediction of Severe Sepsis
The primary objective of this study is to use HBP concentration to indicate the presence, or outcome, of severe sepsis (including septic shock) at admission and to predict the outcome …
Baylor Role: Collaborator
Withdrawn
The Effect of Ticagrelor on 15-Epi-Lipoxin A4 and Inflammation
Clopidogrel, ticagrelor and prasugrel are routinely used for platelet inhibition in addition to aspirin in patients after acute coronary syndromes. The platelet inhibition and patient outcomes (PLATO) trial showed that …
Baylor Role: Lead Sponsor
Terminated
Effect of Dapagliflozin on Inflammation and Endothelial Function
The insulin-resistant state of type 2 diabetes mellitus (T2DM) is largely mediated by inflammatory pathways affecting skeletal muscle which is the primary site of whole body insulin resistance. Nuclear factor …
Baylor Role: Lead Sponsor
Withdrawn
Factors Associated With Increased Risk of Bacteremia and Cholangitis in ERCP With Cholangioscopy
ERCP with cholangioscopy is becoming a widespread technique to treat complicated choledocholithiasis, document CBD clearance after stone extraction and to assess biliary duct strictures. During the procedure, a large amount …
Baylor Role: Lead Sponsor
Completed
Home Away From Home - Medical Outcomes
This is a bidirectional observational cohort study. Participants will be patients less that 19 years of age at diagnosis receiving or having received chemotherapy for AML from seventeen participating pediatric …
Baylor Role: Collaborator