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Technology Development for Noninvasive Prenatal Genetic Diagnosis Using Whole Fetal Cells From Maternal Peripheral Blood (External Link)
This is a revision to a project entitled "Prenatal Genetic Diagnosis by Genomic Sequencing: A Prospective Evaluation." This study proposes to test the utility and accuracy of a new form …
Baylor Role:
Collaborator
Recruiting
Genetic Disorders of Obesity Program Database (External Link)
Children and adolescents who have suffered from severe weight gain prior to 5 years of age and who are seen in the Genetic Disorders of Obesity Program at Texas Children …
Baylor Role:
Lead Sponsor
Recruiting
Linking Endotypes and Outcomes in Pediatric Acute Respiratory Distress Syndrome (External Link)
Investigators will measure pre-determined biomarkers with known or suspected association with ARDS severity or outcome. Simultaneously, investigators will measure gene expression of peripheral blood. Both plasma biomarkers and gene expression …
Baylor Role:
Collaborator
Recruiting
Clinical and Basic Investigations Into Congenital Disorders of Glycosylation (External Link)
The investigators are conducting a natural history study of patients with congenital disorders of glycosylation (CDG). The study will look into the progression of the disease amongst the participants and …
Baylor Role:
Collaborator
Recruiting
Fetal Endotracheal Occlusion (FETO) in the Resolution of Pulmonary Hypertension in Fetuses With Severe CDH (External Link)
Enrollment Women carrying a fetus with severe CDH and a normal karyotype will undergo routine clinical evaluation. The fetus will be 28+0/7 to 31+6/7 weeks of gestational age and have …
Baylor Role:
Collaborator
Recruiting
Prenatal Genetic Diagnosis by Genomic Sequencing (External Link)
Whole exome and whole genome sequencing (WGS) have expanded the ability to determine the genetic etiology of previously undiagnosed disorders. This study is a multicenter prospective cohort study to evaluate …
Baylor Role:
Collaborator
Recruiting
Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell Disease (External Link)
This is a follow-up trial to NYMC 526 (NCT01461837) to assess the safety, efficacy and toxicity of administering Defibrotide prophylaxis for high-risk sickle cell or beta thalassemia patients undergoing a …
Baylor Role:
Collaborator
Recruiting
Prediction of Brain Injury in Premature Infants (External Link)
This is a prospective, single-center, data collection research study for premature ELBW infants at high risk of developing brain injury. This study is being done to evaluate the changes in …
Baylor Role:
Lead Sponsor
Recruiting
Investigation of the Genetics of Hematologic Diseases (External Link)
Participants will be individuals (proband) receiving therapy or expert consultation regarding a non-malignant hematologic disorder. We propose to use genomics, transcriptomics, proteomics and metabolomic analysis coupled with family linkage studies …
Baylor Role:
Collaborator
Recruiting
BBD Longitudinal Study of Osteogenesis Imperfecta (External Link)
The purpose of this natural history study is to perform a long-term follow-up of a large group of people with osteogenesis imperfecta (OI). The research aims are: 1. To collect …
Baylor Role:
Lead Sponsor